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OverviewEpidemiological and genetic studies showed that severity of invasive group A streptococcal (GAS) sepsis is influenced by interactions of genetic factors of both bacteria and host. Systems biology approaches presented shed light on host mechanisms of differential response to invasive GAS sepsis. Using genome-wide association studies, we found association between differential susceptibility to GAS sepsis and quantitative trait loci (QTL) on mouse Chr 2 and X. Genes within these QTLs were prioritized based on bioinformatics and qPCR to explore mechanisms of host differential susceptibility. Collectively, data suggested that prostaglandin and interleukin 1 signaling pathways act as key modulators of a network of genes involved in immune responses to GAS sepsis. In addition, genome-wide transcriptome studies showed that pathways involving activation of interleukin 10 production and signaling are likely to be associated with resistance to infection. Despite differences between mouse and human immune systems, systems biology approaches results using mice corresponded well with results obtained from human studies demonstrating the power of this approach and better translation to humans. Full Product DetailsAuthor: Nourtan AbdeltawabPublisher: LAP Lambert Academic Publishing Imprint: LAP Lambert Academic Publishing Dimensions: Width: 15.20cm , Height: 1.00cm , Length: 22.90cm Weight: 0.254kg ISBN: 9783846510537ISBN 10: 384651053 Pages: 168 Publication Date: 26 September 2011 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In stock We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |