Overview

​​​​​​​​​​​​​​​​​​​​​​​ Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie  environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic ""code"" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned “on” or “off” and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines  - namely, the ""readers, writers and erasers"" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery. What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks.

Full Product Details

Author:   Andrew Emili ,  Jack Greenblatt ,  Shoshana Wodak
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2014 ed.
Dimensions:   Width: 15.50cm , Height: 2.30cm , Length: 23.50cm
Weight:   6.151kg
ISBN:  

9781461479307

ISBN 10:   1461479304
Pages:   316
Publication Date:   09 August 2013
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface.- Systematic proteomic analysis of histone demethylating enzymes linked to cancer.- Histone methylating protein complexes in cancer.- Chromatin protein-protein interaction networks linked to cancer.- Structural genomics and drug discovery for chromatin-related protein complexes involved in histone tail recognition.- Transcription factories and global chromatin (enhancer) interactions in cancer.- Long ncRNAs associated with chromatin complexes and their role in cancer.- Familial and somatic mutations of histone modifying enzymes in cancer.- Chromatin regulators arising from RNAi screens of transformed cancer cell lines.- Chromatin complexes in cancer.- Exploring dynamics of chromatin complexes in cancer based on quantitative proteomics.- Regulatory ncRNAs and their targets.- ncRNA regulatory networks in cancer.- Decoding BAF remodelling complexes in cancer.- Mediator/cohesin complex in cancer.- miRNAs targeting chromatin-related protein complexes regulate epigenetic states in cancer.- Polycomb group protein complexes in cancer stem cells.- Genetic interactions between chromatin factors in cancer cell lines.- Chromatin complexes in DNA repair.- Chromatin complexes in chromosome segregation.- Evolution, co-expression and domain architecture of CM complexes linked to cancer​.- Index.

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