Overview

In the post-genomic era we have, at our fingertips, complete genome sequences and huge numbers of predicted gene sequences from a multitude of complex organisms. There remains, however, the critical need to understand the functions of these gene products to delineate the precise roles of these genes in complex biological milieu. Synthetic nucleic acids are at the cutting-edge of molecular strategies that target genes of interest in a specific and cost-effective manner. These agents are now being used as new and exciting gene-silencing agents in vitro, in animal models of disease, and in humans. This book brings together timely authoritative, in-depth reviews by renowned international leaders in the fields of ribozymes, RNA interference, DNAzymes and oligonucleotide decoys, with emphasis on biochemistry and translational research.

Full Product Details

Author:   Levon Michael Khachigian (University of New South Wales, Australia) ,  Levon Michael Khachigian (University of New South Wales, Australia) ,  Ryuichi Morishita ,  Noboru Fukuda
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Dimensions:   Width: 15.60cm , Height: 1.70cm , Length: 23.40cm
Weight:   0.408kg
ISBN:  

9780849330254

ISBN 10:   0849330254
Pages:   204
Publication Date:   29 November 2004
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Foreword. Therapeutic Application of Ribozymes for Cardiovascular Disease. Development of Ribozymes as Cancer Therapeutics. RNA Interference: A Technology Based on an Ancient Gene Silencing Pathway. RNA-Cleaving DNA Enzymes in Gene Silencing: Room for Improvement? Deoxyribozymes and Medical Innovation. Effect of Modifications on the Intracellular Activity of a DNA Enzyme. Potential Therapeutic Applications of DNA Enzymes and siRNAs Against Viral and Cellular Genes. Use of DNAzymes for Target Gene Validation. DNAzymes Targeting Immediate-Early Genes as Inhibitors of Angiogenesis and Restenosis. Decoy Oligodeoxynucleotides as Viable Pharmaceutical Drugs.

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Levon Michael Khachigian

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