Overview

A comprehensive reference on the synthetic chemistry of cycloaddition reactions Dipolar cycloaddition reactions have found many useful applications in chemistry, particularly with respect to the synthesis of compounds with new chiral centers. Such asymmetric syntheses have a growing importance in the pharmaceutical and agricultural industries with respect to the preparation of chiral drugs and natural products. This much-needed volume updates the popular 1984 edition with advances made over the last twenty years in cycloaddition reactions. While the 1984 volume focused on theory, structure, reactivities, and selectivities, the new volume is geared toward synthetic applications. Both carbonyl ylides and nitronates, important members of the 1,3-dipole family that were not reviewed previously, are now included. Also, beyond the capability of the 1,3-dipolar cycloadditon reaction to produce heterocycles, the ability of heteroatom-containing cycloadducts to transform into a variety of other functionalized organic molecules, cylclic or acyclic, and the ability of many 1,3-dipolar cycloadditions to generate rings containing several contiguous stereocenters in one synthetic operation is discussed. Volume 59 provides the only comprehensive reference on the market detailing the synthetic chemistry of cycloaddition reactions.

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9780471387268

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...very well written, informative, and...not simply a compilation of reactions...certain to be of value to all practitionersA...as well as to members of the pharmaceutical community...a must purchase for all institutions involved in the chemical sciences. (Journal of the American Chemical Society, 2002) ...this is an excellent reference. (The Chemist, Summer 2003)

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