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OverviewSynthesis of Carbohydrates Through Biotechnology discusses the engineering of glycosyltransferases and carbohydrate-active enzymes for preparative purposes, structure-function studies, chemo-enzymatic carbohydrate synthesis, and new approaches on carbohydrate-based drug discoveries. Practitioners in the carbohydrate and genetic engineering fields, especially those in the medicinal, chemical, and pharmaceutical areas, will find this book useful. Carbohydrates and their conjugates occur in biological and immunological processes such as molecular recognition and host-pathogen interactions. Carbohydrate structures also frequently change upon carcinogenic transformation. Glycomics, which is the study of an organism's entire array of oligosaccharides, is now emerging as the third informatics wave after genomics and proteomics. This major area will help us understand the molecular phenotype. Because of the complexities of carbohydrates, the function of the majority of carbohydrates in biological systems still needs to be explored. Although carbohydrates are less interesting targets for drug development, they are important components in many valuable therapeutics such antibiotics and anticancer agents. For these reasons, more reliable technologies to efficiently assemble glycoconjugates are absolutely needed to enable their studies. Full Product DetailsAuthor: Peng George Wang (Professor, Professor, Wayne State University) , Yoshi Ichikawa (Researcher, Researcher, Optimer Pharmaceuticals, Inc.)Publisher: Oxford University Press Inc Imprint: Oxford University Press Inc Volume: 873 Dimensions: Width: 16.00cm , Height: 1.50cm , Length: 23.70cm Weight: 0.377kg ISBN: 9780841238657ISBN 10: 0841238650 Pages: 208 Publication Date: 04 March 2004 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: No Longer Our Product Availability: Out of stock  The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsPreface 1: Przemyslaw Kowal, Jun Shao, Mie Li, Wen Yi, Hanfen Li, and Peng George Wang: Approaches to the Enzymatic Carbohydrate Synthesis 2: Obadiah J. Plante: Exploring Carbohydrate Diversity through Automated Synthesis 3: Shirley A. Wacowich-Sgarbi, David Rabuka, Paulo W.M. Sgarbi, and Yoshi Ichikawa: Glycosynthesis for Drug Discovery:Globo H Synthesis by OPopS 4: Ruby Wang, Brian J. Trummer, Ellen Gluzman, Chao Deng, and Denong Wang: Probing the Antigenic Diversity of Sugar Chains 5: Fengyang Yan, Seema Mehta, Eva Eichler, Warren Wakarchuk, and Dennis M. Whitfield: Chemoenzymatic Synthesis of Lactosamine and (a2-3) Sialylated Lactosamine Building Blocks 6: Lai-Xi Wang, Suddham Singh, and Jiahong Ni: Synthesis of Bioactive Glycopeptides through Endoglycosidase-Catalyzed Transglycosylation 7: Ola Blixt and Nahid Razi: Strategies for Synthesis of an Oligosaccharide Library Using a Chemoenzymatic Approach 8: Shin-Ichiro Nishimura, Noriko Nagahori, Reiko Sadamoto, Kenji Monde, and Kenichi Nikura: Artificial Golgi Apparatus: Direct Monitoring of Glycosylation Reactions on Automated Glycosynthesizer 9: Paul L. DeAngelis: Sugar Engineering with Glycosaminoglycan Synthases 10: Laure Jolly, Veronique Tornare, and Sunil Kochhar: Production of Oligosaccharides Using Engineered Bacteria: Engineering of Exopolysaccharides from Lactic Acid Bacteria 11: Satoshi Koizumi: Production of Oligosaccharides by Coupling Engineered Bacteria 12: Mei Li, Jun Shao, Min Xiao, and Peng George Wang: Synthesis of Glycoconjugates through Biosynthesis Pathway Engineering Author Index Subject IndexReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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