Overview

The exponential growth in our knowledge on the pathophysiology of hypothalamic-pituitary-thyroid axis and, in particular, of thyroid hormone action, largely stems from the studies on the various syndromes of resistance to the hormones involved in the function of the axis. These syndromes essentially encompass two forms, i. e. the resistance to thyroid hormones and that to TSH action. The contribution of molecular biology has been fundamental in understanding the etiology of these different thyroid disorders and led to the discovery of new pathogenetic mechanisms, e. g. the dominant negative effects of a mutant protein on the normal one. In this book, I have assembled an internationally renewed group of experts devoted to the studies of both basic and clinical thyroidology. Taking the syndromes of resistance as a template, the novelties on the mechanisms of action of the various hormones, the etiopathogenesis of the syndromes, the instruments for the diagnosis, as well as the pitfalls in managing these diseases, are deeply revisited. The insights from different animal models are discussed, with particular focus on tissue specific action of thyroid hormones, as well as on the still enigmatic mechanism of negative feedback control of thyroid hormones on TSH secretion and the different etiologic mechanisms causing thyroid hormone resistance in patients without mutations in the thyroid hormone receptor ~. The role of the structure of thyroid hormone and TSH receptors in designing agonist or antagonist molecules is extensively debated. Moreover, new forms of congenital or acquired resistance to thyroid hormones are presented.

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9781475710656

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"""Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis is a tour-de force by expert authors in the field of thyroid hormone action. Using clinical syndromes of thyroid hormone and TSH resistance, they explore the fundamental mechanisms for thyroid hormone structure-function defects and translate these fascinating molecular observations into an understanding of the pathogenesis of human disease. Endocrinologists, internists, pediatricians and students of the thyroid axis and hormone action will enjoy the depth and breadth of information which has been assembled by the Editor to provide a truly unique cutting edge state of the art."" (Shlomo Melmed, M.D., Series Editor, ""Endocrine Updates)"

Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis is a tour-de force by expert authors in the field of thyroid hormone action. Using clinical syndromes of thyroid hormone and TSH resistance, they explore the fundamental mechanisms for thyroid hormone structure-function defects and translate these fascinating molecular observations into an understanding of the pathogenesis of human disease. Endocrinologists, internists, pediatricians and students of the thyroid axis and hormone action will enjoy the depth and breadth of information which has been assembled by the Editor to provide a truly unique cutting edge state of the art. (Shlomo Melmed, M.D., Series Editor, Endocrine Updates)

Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis is a tour-de force by expert authors in the field of thyroid hormone action. Using clinical syndromes of thyroid hormone and TSH resistance, they explore the fundamental mechanisms for thyroid hormone structure-function defects and translate these fascinating molecular observations into an understanding of the pathogenesis of human disease. Endocrinologists, internists, pediatricians and students of the thyroid axis and hormone action will enjoy the depth and breadth of information which has been assembled by the Editor to provide a truly unique cutting edge state of the art. (Shlomo Melmed, M.D., Series Editor, Endocrine Updates)

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