Sustainable Quality Improvements for Isotope Dilution in Molecular Ultratrace Analyses: Fitness for Purpose, Performance-Based Criteria, and Measurement Uncertainty

Author:   Yves Tondeur (Founder and CEO, It’s About Purpose, LLC, USA)
Publisher:   Elsevier - Health Sciences Division
ISBN:  

9780443290343


Pages:   736
Publication Date:   26 April 2024
Format:   Paperback
Availability:   Not yet available   Availability explained
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Sustainable Quality Improvements for Isotope Dilution in Molecular Ultratrace Analyses: Fitness for Purpose, Performance-Based Criteria, and Measurement Uncertainty


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Author:   Yves Tondeur (Founder and CEO, It’s About Purpose, LLC, USA)
Publisher:   Elsevier - Health Sciences Division
Imprint:   Elsevier - Health Sciences Division
Weight:   0.450kg
ISBN:  

9780443290343


ISBN 10:   0443290342
Pages:   736
Publication Date:   26 April 2024
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Not yet available   Availability explained
This item is yet to be released. You can pre-order this item and we will dispatch it to you upon its release.

Table of Contents

1. Spotlight on the Issues 2. The Path to Current Reality 3. Quality Improvement Movements 4 Self-referential principle and enfolded performance concept 5. Quality-Generating Assays 6. Batch Control Spike 7. Performance-Based Criteria Analysis 8. Innovation Platform 9. Revisiting Traditions 10. The right, legal, and correct answers Appendices A: Guideposts for core steps B: Limits of detection (LOD) and quantitation (LOQ) C: Measurement of uncertainty D: What’s our focus? E: Audit samples — Method 301 PLQ — Method 23 final rule F: Method 1668 validation study G: New formation mechanism in secondary aluminum smelter H: Insights into the origin of dioxins in ancient tertiary clays I: Performance assessment—A vision J: Method detection limits K: Artifact and vigilance L: LOQ validation M: Percent valley N: SQI-relevant definitions O: SQI charts P: Reference values References Reflections pool

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Yves Tondeur is the Founder and CEO of It’s About Purpose, LLC, based in the USA. He graduated from the Free University of Brussels with a Ph.D. in Chemistry. Post-doctoral research work in the field of analytical organic mass spectrometry entailed the applications of negative chemical ionization mass spectrometry to trace analyses of chlorinated aromatic compounds, interfacing the sample preparation and mass spectrometry laboratories while developing and optimizing analytical procedures for substances of concern. He developed the original version of USEPA Method 8290 in support of the Superfund Program before rejoining a group of former scientists and colleagues who founded a commercial laboratory. He consistently and determinatively promoted the benefits of isotope dilution for measuring trace levels of toxic compounds, refined the original version of Method 8290 leading to the analytical portion of Method 23 for stack emissions, and Method 1613. During his tenure at Analytical Perspectives, efforts toward improvements in methodologies continued with a special emphasis on understanding the technology, how it differentiates itself from older methods and other technologies, and how a genuine performance-based approach could be materialized.

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