Overview

Over a decade ago, a small cellular protein of 12 kDa, with 18% homology to the well-known ubiquitin protein, was co-discovered and termed Small Ubiquitin-like Modifier, or SUMO. Sumoylation is a post-translational modification that utilizes SUMO as the modifier group covalently attached to target substrates. This state-of-the art review on the sumoylation system deals with protein modification as it pertains to regulation of diverse cellular functions. Each chapter has been written by a leading researcher and covers the role of sumoylation in fundamental biochemical activities (transcription, RNA processing, chromatin remodelling, DNA repair, nucleocytoplasmic transport, ion channel regulation, and metabolic pathways). The text also examines the part sumoylation plays in critical cellular processes such as mitosis, meiosis, differentiation, senescence, and apoptosis. Lastly, the emerging role of sumoylation in specific diseases, including cancer and diabetes as well as neurodegenerative ones, is explored with an emphasis on defining molecular mechanisms that may provide new targets for treatment or prevention. While SUMO was discovered more than 10 years ago, this is still a relatively young field, and much remains to be discovered about the biochemical and biological properties of this modification system. In just the last few years, it has become clear that sumoylation modifies hundreds of cellular proteins, and there has been increased appreciation for the breadth of cellular functions that are impacted by this post-translational modification.

Full Product Details

Author:   Van G. Wilson
Publisher:   Springer
Imprint:   Springer
Dimensions:   Width: 15.60cm , Height: 2.00cm , Length: 23.40cm
Weight:   0.669kg
ISBN:  

9789048126484

ISBN 10:   9048126487
Pages:   339
Publication Date:   08 December 2009
Audience:   Professional and scholarly ,  Professional & Vocational
Replaced By:   9783319500430
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Chapter 1: Introduction to Sumoylation Molecular Functions Chapter 2: SUMO Modification and Transcriptional Regulation Chapter 3: Emerging Roles for SUMO in mRNA Processing and Metabolism Chapter 4: SUMO and Chromatin Remodeling Chapter 5: Functions of SUMO in the Maintenance of Genome Stability Chapter 6: SUMO and Nucleocytoplasmic Transport Chapter 7: SUMO Modification of Ion Channels Chapter 8: The Role of Sumolyation in Metabolic Regulation Cell Growth Regulation Chapter 9: The SUMO Pathway in Mitosis Chapter 10: Wrestling with Chromosomes: The Roles SUMO during Meiosis Chapter 11: Sumoylation in Development and Differentiation Chapter 12: The Role of Sumoylation in Senescence Chapter 13: Sumoylation and Apoptosis Diseases Chapter 14: The Role of Sumoylation in Neurodegenerative Diseases Chapter 15: Sumoylation and its Contribution to Cancer Chapter 16: SUMO4-encoded Genetic Susceptibility to Type 1 Diabetes Chapter 17: Sumoylation in Craniofacial Disorders Chapter 18: Viral Interplay with the Host Sumoylation System

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