Overview

This is the second edition of a very well received book that details how the sumoylation system functions and how it modulates numerous cellular activities. SUMO is a post-translational modifier in the ubiquitin super-family that has gained recognition over the last twenty years as an essential and prevalent regulatory molecule. Individual chapters explore the biochemistry, molecular biology, and cell biology of the sumoylation system and its substrate proteins. The book is divided into three themed parts: Molecular Functions (I), Cell Growth Regulation (II), and Diseases (III). Parts I and II focus on the contribution of sumoylation to cellular activities in both the nuclear and cytoplasmic compartments. The nuclear activities covered include nucleic acid metabolism (both RNA and DNA), chromosome structure and replication, and nucleocytoplasmic transport. Cytoplasmic processes presented include regulation of membrane ion channels, general metabolism, and apoptotic signalling. Topics in Part III include the role of sumoylation in developmental abnormalities (craniofacial and cardiovascular), diabetes, neurodegenerative diseases, cancer, and infections with viruses and bacteria. Each of the corresponding chapter authors is an active researcher who has made significant contributions to understanding sumoylation. This second edition provides updates and revisions to most of the original chapters plus adds six new chapters to address important developing areas of sumoylation research. This volume is intended for a scientific audience from undergraduates to independent researchers. The content will serve as both a solid introduction for the novice reader and an in depth treatment for the advanced scholar.

Full Product Details

Author:   Van G. Wilson
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 2nd ed. 2017
Volume:   963
Weight:   7.917kg
ISBN:  

9783319843049

ISBN 10:   3319843044
Pages:   415
Publication Date:   20 June 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface 1. Introduction to Sumoylation V.G. Wilson   Part I Molecular Functions        2. Roles of Sumoylation in mRNA Processing and Metabolism P. Richard, V. Vethantham and J.L. Manley   3. SUMO and Chromatin Remodeling D. Wotton, L.F. Pemberton, and J. Merrill-Schools   4. Functions of SUMO in the Maintenance of Genome Stability N. Zilio, K. Eifler-Olivi, and H.D. Ulrich   5. Regulation of Cellular Processes by SUMO: Understudied Topics J.M. Enserink   6. The Molecular Interface Between The SUMO And Ubiquitin Systems J.L. Staudinger   7. SUMO and Nucleocytoplasmic Transport Christopher Ptak and Richard W. Wozniak<   8. SUMO Modification of Ion Channels M. Benson, J.A. Iñiguez-Lluhí, and J. Martens   E. Kamynina and P.J. Stover   Part II Cell Growth Regulation   10. The SUMO Pathway in Mitosis D. Mukhopadhyay and M. Dasso   11. Wrestling with Chromosomes: The Roles of SUMO During Meiosis A.C. Nottke, H.-M. Kim, and M.P. Colaiácovo   12. Sumoylation in Development and Differentiation A.F. Deyrieux and V.G. Wilson    13. The Role of Sumoylation in Senescence L.L. Scurr, S. Haferkamp, and H. Rizos   14. Regulation of Plant Cellular and Organismal Development by SUMO N. Elrouby   15. SUMO in Drosophila Development J. Cao and A. Courey    Part III Diseases   16. SUMOylation: Implications for Neurodegenerative Diseases D.B. Anderson, C.A. Zanella, J.M. Henley, and H. Cimarosti   17. Sumoylation and Its Contribution to Cancer J.S. Lee, H.J. Choi, and S.H. Baek   18. Sumoylation Modulates the Susceptibility to Type 1 Diabetes J. Zhang, Z. Chen, Z. Zhou, P. Yang, and C.-Y. Wang   19. Sumoylation in Craniofacial Disorders E. Pauws and P. Stanier   20. Coordination of Cellular Localization-Dependent Effects of Sumoylation in Regulating Cardiovascular and Neurological Diseases J. Abe, U.G. Sandhu, N.M. Hoang, M. Thangam, R.A Quintana-Quezada, K. Fuiwara, and N.T. Le   21. Viral Interplay with the Host Sumoylation System A.F. Deyrieux and V.G. Wilson   22. SUMOylation as an Integral Mechanism in Bacterial Infection and Disease   Pathogenesis C.V. Srikanth and S. Verma Index        <    

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