Overview

Substance P: From Pain to Cancer, a volume in the Molecular Mediators in Health and Disease: How Cells Communicate series, provides a complete discussion of substance P biology, its role in normal physiology and a variety of diseases. The volume provides an introduction to substance P and its pharmacology, followed by exploring its role across the human body including cardiovascular function, micturition, learning and memory, emesis, respiration and sleep. It then discusses the critical role of substance P in several disease states including acute brain injury, neurodegeneration, seizures, depression and anxiety, cancer, musculoskeletal disorders, and viral infection, including COVID-19. The book closes with a look towards future perspectives for substance P. Substance P: From Pain to Cancer is an ideal reference for researchers across the life sciences interested in understanding the role of this multi-functioning mediator and its biological significance.

Full Product Details

Author:   Robert Vink (Consultant (Biotechnology, Legal, Higher Education) Vink NeuroConsulting, Mylor, Australia)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.450kg
ISBN:  

9780443221941

ISBN 10:   0443221944
Pages:   550
Publication Date:   21 November 2024
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
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Table of Contents

Part I: Introduction to Substance P 1. The synthesis, release and binding of substance P 2. The anatomical distribution of substance P receptors 3. Substance P in non-mammalian biology Part II: Substance P pharmacology 4. Measurement of substance P 5. Substance P antagonists Part III: Substance P in organ function 6. Substance P in the gut 7. Substance P in the cardiovascular system 8. Substance P in the renal system and micturition 9. Substance P in learning and memory 10. Substance P in the central control of nausea and vomiting 11. Substance P in CNS reward and addition 12. Substance P in sleep 13. Substance P in the central control of respiration 14. Substance P in pain 15. Substance P in bone metabolism 16. Substance P in platelet aggregation and would healing 17. Life without substance P – the naked mole rat Part IV – Substance P in Disease 18. Substance P in inflammation 19. Substance P in oxidative stress 20. Substance P in cancer 21. Substance P in the cardiac dysfunction 22. Substance P in neurotrauma 23. Substance P in stroke 24. Substance P in concussion and CTE 25. Substance P in Parkinson’s disease and Alzheimer’s disease 26. Substance P in depression 27. Substance P in stress and anxiety 28. Substance P in seizures and epilepsy 29. Substance P in musculoskeletal disorders 30. Substance P in acupuncture 31. Substance P in cough and asthma 32. Substance P in sudden infant death syndrome (SIDS) 33. Substance P in in immunity 34. Substance P in infection (non-viral) 35. Substance P in viral infection including COVID-19 36. Substance P In pruritis 37. Substance P in alopecia 38. Controversies in clinical translation 39. Future directions and perspectives

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Author Information

Robert Vink is an Emeritus Professor at the University of South Australia and is currently Chair of the Board for Connectivity: Traumatic Brain Injury Australia. He was previously appointed as the Professor and Chair of Neurosurgical Research and Head of School, Medical Sciences at the University of Adelaide, Australia. Throughout his time as a teaching/research academic he led a highly productive research group and maintained an extensive publication output. He is the author of over 260 articles and book chapters. He has supervised more than 30 graduate research students, many of whom now hold significant academic and other positions throughout Australia and internationally. He is known internationally for his work in traumatic brain injury and has received numerous prestigious awards and appointments related to this. He currently provides research consulting services to universities and the pharmaceutical industry.

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