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OverviewThis is a discussion of the properties that follow from the principles of thermodynamics, aiming to bridge the gap in showing applications of model molecules in modern drug design. The book connects two subjects: drug design - a biological science - and thermodynamics - a physical science. Armed with the knowledge of the three-dimensional structure of a potential binding site of a molecule, the method of structure-based design provides a rapid, rational route to a ligand molecule. Recent developments in the determination of structure and the measurement of thermodynamic parameters of binding have resulted in drawing theoretical and experimental data together to improve ability to model these interactions afresh. The book also outlines future developments in the field of structure-based ligand design. Full Product DetailsAuthor: J.E. Ladbury , P.R. ConnellyPublisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K Weight: 0.455kg ISBN: 9783540632504ISBN 10: 3540632506 Pages: 198 Publication Date: 17 October 1997 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Temporarily unavailable The supplier advises that this item is temporarily unavailable. It will be ordered for you and placed on backorder. Once it does come back in stock, we will ship it out to you. Table of ContentsApplications of free energy calculations to drug design; energetic dissection of specificity in serine proteases; model compounds and interpretation of protein-ligand interactions; a structure-based thermodynamic approach to molecular design; the cost of release site-specific, bound water molecules from proteins - toward a quantitative guide for structure-based drug design; exploring unchartered waters - water molecules in drug design strategies.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |