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OverviewStructural genomics is the study of the DNA of living organisms. Evolutionary genomics is the study of the history of the genome. These subjects are closely interlinked. They are approached in this book using as a guideline the investigations carried out in the author's laboratory, relevant literature is critically reviewed and some general conclusions are presented. The author and his collaborators have studied a vast number of genomes, ranging from prokaryotes to human, using different approaches, including physical chemistry of DNA, viral integration and molecular cytogenetics. As the subtitle indicates the book discusses the fundamental importance of natural selection in shaping genomes. In terms of numbers, neutral and nearly neutral mutations represent most mutations, but a regional control is exerted by natural selection (essentially negative or purifying selection). A neo-selectionist model is proposed for genome evolution. . Summarizes the existing knowledge on genome organization and evolution in a self-containedbook. Discusses important open problem, without refraining from criticism wheneverappropriate Full Product DetailsAuthor: Giorgio Bernardi (Institut Jacques Monod, Paris, France) , Georgio BernardiPublisher: Elsevier Science Imprint: Elsevier Science ISBN: 9781281227362ISBN 10: 1281227366 Pages: 458 Publication Date: 01 January 2005 Audience: General/trade , General Format: Undefined Publisher's Status: Active Availability: In stock We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |