Overview

This detailed volume brings together a diverse collection of stem cell-derived model-based toxicity assays, from those routinely used to those deemed to have considerable potential. With a focus on differentiated tissues, the chapters explore numerous cardiotoxicity applications as well as coverage of neurotoxicity, hepatotoxicity, and more. Written for the Methods in Pharmacology and Toxicology series, the contents of this book aim to enable adoption of these protocols in laboratories that are interested in entering the field as well as to facilitate the transfer of best practices between laboratories that are already actively pursuing these technologies.  Authoritative and cutting-edge, Stem Cell-Derived Models in Toxicology serves as a vital resource for researchers aiming to improve risk assessment in drug discovery and design.

Full Product Details

Author:   Mike Clements ,  Liz Roquemore
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   1st ed. 2017
Dimensions:   Width: 17.80cm , Height: 2.10cm , Length: 25.40cm
Weight:   8.123kg
ISBN:  

9781493966592

ISBN 10:   1493966596
Pages:   341
Publication Date:   26 November 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Stem Cell‐Derived Models for Safety and Toxicity Assessments: Present and Future Studies in the “Proclinical Space”.- Human Pluripotent Stem Cell Test for Assessing the Potential Teratogen Risk.- Cardiac Action Potential Measurement in Human Embryonic Stem Cell Cardiomyocytes for Cardiac Safety Studies Using Manual Patch-Clamp Electrophysiology.- Automated Patch Clamp Recordings of Human Stem Cell-Derived Cardiomyocytes.- The CiPA Microelectrode Array Assay with hSC-Derived Cardiomyocytes: Current Protocol, Future Potential.- Optogenetic Approach to Cardiotoxicity Screening: Simultaneous Voltage and Calcium Imaging Under Paced Conditions.- HTS Compatible Voltage- and Ca2+-Sensitive Dye Recordings from hiPSC-Derived Cardiomyocytes Using the Hamamatsu FDSS Systems.- Kinetic Image Cytometry for Predicting Arrhythmias Using Human Stem Cell-Derived Cardiomyocytes.- Decoding Ca2+ Signals as a Non-Electrophysiological Method forAssessing Drug Toxicity in Stem-Cell Derived Cardiomyocytes.- Combined Impedance and Extracellular Field Potential Recordings from Human Stem Cell-Derived Cardiomyocytes.- Edge Detection for Contractility Measurements with Cardiac Spheroids.- Contractile Force Readout of hESC-Cardiomyocytes.- In Vitro Cardiotoxicity Investigation Using High Content Analysis and Human Stem Cell-Derived Models.- Structural Toxicity: Hypertrophy Models of Human Pluripotent Stem Cell-Derived Cardiomyocytes.- Addressing Functional Neurotoxicity Using the Microelectrode Array (MEA).- Micropatterned Co-Cultures of Induced Pluripotent Stem Cell-Derived Hepatocytes and Stromal Cells for Drug Toxicity Studies.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions