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Author:   Ajaykumar Vishwakarma ,  Paul Sharpe ,  Songtao Shi ,  Murugan Ramalingam
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
ISBN:  

9780128101209

ISBN 10:   0128101202
Pages:   932
Publication Date:   30 October 2017
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
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Table of Contents

Part 1: Developmental Biology: A Blueprint for Tissue Engineering Part 2: In Vitro Regulation of Cell Behaviour and Tissue Development Part 3: Biomaterials in Tissue Engineering Part 4: Oral and Craniofacial Stem Cells for Tissue Engineering Part 5: Tooth Tissue Engineering Part 6: Tissue Engineering in Endodontics Part 7: Periodontal Tissue Engineering Part 8: Craniofacial Tissue Engineering Part 9: Bioengineering Organs in Head and Neck Part 10: Tissue Engineering Skin and Oral Mucosa Part 11: Tissue Engineered Implant Dentistry Part 12: Tissue Engineering in Orthodontics & Dentofacial Orthopedics Part 13: Transplantation of Engineered Tissue Constructs Part 14: Research Ethics and Law

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Author Information

Dr Ajaykumar Vishwakarma works for the Division of Engineering in Medicine, Department of Medicine, at Brigham and Women's Hospital, as well as the Harvard-MIT Division of Health Sciences and Technology at the Massachusetts Institute of Technology. He graduated from Maharashtra University of Health Science, India with a B.D.S degree and has been a recipient of the Stem Cell Training Fellowship at Centre for Cellular and Molecular Biology. He completed his MSc in Tissue Engineering and PG Certificate in Biomedical Techniques from Cardiff University, UK. Additionally, he has held key industrial positions in the past to gain experience in commercialization and translational biotechnology. Dr. Vishwakarma's areas of specialization include innovation using bioengineering design principles to develop advanced therapeutic and non-therapeutic tissue engineered products for healthcare and to improve sustainability. His primary research addresses understanding the physical and biochemical properties of the extracellular matrix (ECM) and further designing cell-instructive biomaterials using micro- and nano-scale technologies to model synthetic somatic or stem cell niches in tissue regeneration. Specific focus is on vascularization, immunomodulation, bone, cartilage and tumors. Professor Paul Sharpe is the Dickinson Professor of Craniofacial Biology at Kings College London. He graduated with a degree in biology from York University (1977) and a PhD in biochemistry from Sheffield University (1981). Following postdocs in Sheffield, Wisconsin and Cambridge he became lecturer in molecular embryology at the University of Manchester in 1987 where he established a research group working on the molecular control of tooth development. Following promotion to Reader in 1991 he was recruited to his present Chair at the Dental Institute of Guy's Hospital (later to merge with Kings College), where he established a new basic research department, the Department of Craniofacial Development and Stem Cell Biology. The department, of which he remains head, now consists of 13 academic research groups with over 80 research staff. From 2002-2008 he was Director of Research for the Dental Institute. His main research interests are the molecular control of tooth development, dental stem cell biology and tooth bioengineering. He has published over 270 research papers including articles in Nature, Science, PNAS and Cell press. He has supervised over 40 PhD students and receives funding from the MRC. He is a member of the MRC Centre for Transplantation and Biomedical Research Centre. In 2004 he was awarded the Craniofacial Biology Research Award by the International Association for Dental Research in recognition of his contribution to the understanding of how teeth develop and in 2006 his paper Stem cell-based tissue engineering of teeth received the William J Gies award for best publication is Biomaterials and Bioengineering from the same organisation. He is on the editorial boards of several journals including J. Dent. Res. and J. Clin. Perio. Songtao Shi, D.D.S., Ph.D., is Professor at the University of Southern California Ostrow School of Dentistry. Dr. Shi received his D.D.S. degree and certificate in Pediatric Dentistry from the Peking University School of Stomatology and Ph.D. in Craniofacial Biology from the University of Southern California. Prior to joining the faculty at the University of Southern California, he served as a Principal Investigator and Clinical Fellow for nine years at the National Institute of Dental and Craniofacial Research. His research program focuses on understanding mechanism of mesenchymal stem cell (MSC)-associated diseases, developing new experimental disease models, and exploring feasibility of translating these bench discoveries to clinical therapies. His group and his collaborators were the first to identify dental pulp stem cells, baby tooth stem cells, periodontal ligament stem cells, root apical papilla stem cells, tendon stem cells, gingiva stem cells, sclera MSCs, and benign tumor MSCs from keloid and ossifying fibroma. In translational study, Dr. Shi's team has used these stem cells to regenerate a variety of tissues, including dentin, pulp, periodontal ligament, tendon, bone, bio-root. Dr. Shi and his collaborators were the first to use MSCs to treat systemic lupus erythematosus (SLE), periodontitis, bisphosphonate-related osteonecrosis of the jaw-like disease (BRONJ) in animal models and patients. Additionally, Dr. Shi and his collaborators were the first to generate BRONJ, osteoradionecrosis, keloid, and ossifying fibroma diseases in mouse and swine models. To understand mechanisms of MSC-based therapies, Dr. Shi's team revealed that MSC mediated bone regeneration was regulated by recipient T cell, which is the pioneer study showing association between cell-based tissue engineering and immune response. Additionally, Dr. Shi and his collaborators discovered that MSC-mediated immunotherapy in human and mouse model is associated the interplay between the donor cells and recipient T cells via Fas/FasL pathway. Recently, Dr. Shi's team first time showed that MSCs contribute to orofacial benign tumor development via an epigenetic regulation network. Dr. Shi has published more than 150 peer-reviewed articles in a variety of high-impact scientific journals, of which he served as the corresponding author in Nat Medicine, Cell Stem Cell, Lancet, J Clin Invest, Nat Biotechnol, Proc Natl Acad Sci U S A, Cell Research, Blood, J Bone Miner Res, Stem Cells, PLoS ONE, and J Dent Res. Dr. Shi's research is supported by NIH grants and funding from California Institute of Regenerative Medicine. Dr. Shi has served on several local and national committees and boards including Scientific Editor for the PLoS ONE and Associate Editor for Oral Diseases. He is recipient of the 2013 IADR Distinguished Scientist Award for Pulp Biology & Regeneration. He is on the editorial board of Stem Cell Research & Therapy, the editorial board of World Journal of Stem Cells, and the editorial board of Chinese Journal of Dental Research. Dr. Shi is Changjing Scholar in the Fourth Military Medical University, Distinguished Visiting Professor in Tongji University, Visiting Professor in XiangYa School of Medicine & Stomatology, Central South University (CSU), and distinguished visiting professor in Dankook University, Korea. Dr. Murugan Ramalingam is Associate Professor at the Centre for Stem Cell Research (a unit of the Institute for Stem Cell Biology and Regenerative Medicine-Bengaluru), Christian Medical College Campus, India. Concurrently he is Adjunct Associate Professor at the Tohoku University, Japan. Prior to joining the CSCR, he was Associate Professor of Biomaterials and Tissue Engineering at the Institut National de la Sante et de la Recherche Medicale, Faculte de Chirurgie Dentaire, Universite de Strasbourg, France. He has worked at the WPI Advanced Institute for Materials Research, Japan, as an Assistant Professor. He has also worked at the National Institute of Standards and Technology (NIST) and the National Institutes of Health (NIH), under the U.S. National Academies Associateship program. He received his Ph.D. in Biomaterials from the University of Madras. He has also undergone training in Ethical and Policy issues on Stem Cells from Harvard University, USA, and in Operations Management from the University of Illinois-Chicago. His current research interests are focused on the development of multiphase biomedical materials, through conventional to nanotechnology to biomimetic approaches, microfabrication, cell patterning, stem cell differentiation, tissue engineering and drug delivery. He is the author of over 190 publications, including peer-reviewed journal papers, conference proceedings, book chapters, authored books, edited books, and patents relevant to biomaterials, stem cells, and tissue engineering. His current h-index is 22. He has organized several international conferences and chaired Biomaterials, Nanobiotechnology, Stem Cells and Tissue Engineering sessions. He also serves as a board member of several international scientific and research committees in various public and private bodies and grant reviewer of various international funding agencies. He serves on the editorial boards of multiple biomaterials and tissue engineering-related journals, including as the Editor-in-Chief of the Journal of Biomaterials and Tissue Engineering, the Journal of Bionanoscience and the American Journal of Stem Cell Research. He is a recipient of several prestigious fellowships and awards, including CSIR Fellowship (India), SMF Fellowship (Singapore), NRC National Academies Fellowship (USA), Nationale Professeur des Universites (France), Fellow of Institute of Nanotechnology (UK) and Fellow of Royal Society of Chemistry (UK).

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