Overview

The era of big data and personalized spine care has arrived. Within that, imaging and clinical phenotypes are key in establishing personalized algorithms for patient care. This is particularly important in developing novel diagnostics and therapeutics as well as predicting outcomes and establishing preventative measures for various spinal disorders. Spine Phenotypes is a comprehensive resource that outlines phenotype descriptions, their imaging measurements and classifications, and provides an in-depth discussion regarding spine pathology and its clinical relevance. Multiauthored, with multidisciplinary contributions from world leaders in the field of imaging, spine research, and clinical practice, each chapter is rich in visual depiction of imaging phenotypes, providing examples of some established phenotypic measurements with a range of normal and pathologic images and their clinical implications. Spine Phenotypes will be a first of its kind reference for spine researchers, clinicians, and industry.

Full Product Details

Author:   Dino Samartzis (Director, International Spine Research and Innovation Initiative (ISRII), Associate Professor, Department of Orthopedic Surgery, Rush Medical College, Chicago, Illinois) ,  Jaro I. Karppinen (Center for Life Course Health Research, University of Oulu, Oulu, Finland) ,  Frances M.K. Williams (King’s College London and Honorary Consultant in Rheumatology, Guy’s and St. Thomas’ NHS Foundation Trust)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   1.020kg
ISBN:  

9780128227787

ISBN 10:   0128227788
Pages:   416
Publication Date:   14 July 2022
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Anatomy of the spine 2. Biomechanics of the spine 3. Biomechanical models to study spinal phenotypes 4. Animal models to study spinal intervertebral disc phenotypes 5. Imaging technologies of the spine 6. Intervertebral disc degeneration 7. Disc space narrowing and osteophytes 8. Displacement of intervertebral discs 9. High-intensity zones and annular tears 10. Vertebral endplate abnormalities, defects, and changes 11. Vertebral bone marrow (Modic) changes 12. Ossification of the posterior longitudinal ligament 13. Lumbar spinal stenosis 14. Facet joints 15. Paraspinal muscles 16. Spinal alignment

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Author Information

Dr. Samartzis obtained his undergraduate degree from Northwestern University, and further pursued graduate studies in biological sciences, evidence-based health care, clinical epidemiology, medical sciences, and international studies at Harvard University, University of Oxford (UK), University of Cambridge (UK), Erasmus University (The Netherlands), Charles University (Czech Republic), and London School of Economics and Political Science (UK). He completed a postdoctoral fellowship at the The University of Hong Kong. He went on to become the Gilbert Beebe Fellow of the Radiation and Nuclear Board of the National Academies of Science in Washington D.C. and the United States Department of Energy, the Radiation Epidemiology Branch of the National Institutes of Health in Bethesda, Maryland, and at the Radiation Effects Research Foundation (a.k.a. Atomic Bomb Casualty Commission) in Hiroshima, Japan. He has published over 350 peer-reviewed studies in high-impact journals (e.g., Lancet, Arthritis & Rheumatism, JBJS, etc.), book chapters and web-based articles. Jaro Karppinen is Professor of Physical and Rehabilitation Medicine at the Institute of Clinical Medicine, University of Oulu, in Northern Finland. He also works at the Finnish Institute of Occupational Health as a specialist of Physical and Rehabilitation Medicine. He has an academic degree in Biochemistry and has been an investigator in many clinical studies related to low back pain and sciatica. His current research interest has focused on environmental and genetic risk factors of degenerative spinal disorders with a special focus on the etiology and diagnostics of Modic changes. He is the Project Leader of the musculoskeletal subprojects of the Northern Finland Birth Cohorts and a Member of the Executive Group the Northern Finland Birth Cohorts. He is a member of the International Society for the Study of the Lumbar Spine, International Association for the Study of Pain, European Spine Society, and AOSpine Research Network. Frances M.K. Williams is a professor at King’s College London and an honorary consultant in rheumatology at Guy’s and St. Thomas’ NHS Foundation Trust. She’s been a member of the Royal College of Physicians since 1995, completed her PhD at the University of London in 2002 and is also a Fellow at the Royal College Physicians of Edinburgh since 2007. Dr. Williams performs genetic and epidemiological studies in Twins UK and UK Biobank volunteers, as well as patients, to understand better the genetic basis for common conditions such as back pain, age-related hearing impairment and fibromyalgia. The areas of special interest are: intervertebral disc degeneration and low back pain, osteoporosis and vertebral fracture, and chronic pain syndrome. Dr. Williams was the International Society for the Study of Lumbar Spine prizewinner for clinical studies in both 2015 and 2019 and has authored 120+ articles.

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