Overview

This volume deals with all the known aspects of somatostatin, one of the phylogenetically oldest hormones, which is a regulatory peptide with remarkable characteristics. It is a non-classical neurotransmitter discovered less than 20 years ago in both the central nervous system and in the gastroenteropancreatic system, regulating the secretion of both pituitary and digestive hormones. It also ensures nutrient homeostasis and has therapeutic uses.

Full Product Details

Author:   Y.C. Patel ,  J. Epelbaum ,  D.R. Rubinow ,  C.L. Davis
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1992
Volume:   4
Dimensions:   Width: 21.00cm , Height: 0.40cm , Length: 27.70cm
Weight:   0.300kg
ISBN:  

9783540545699

ISBN 10:   3540545697
Pages:   66
Publication Date:   17 July 1992
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

General Aspects of the Biology and Function of Somatostatin.- Molecular Heterogeneity of Somatostatin.- Evolution of Somatostatin Genes and Gene Products.- Anatomical Distribution of Somatostatin Cells.- Somatostatin in the Blood and Other Body Fluids.- Actions of Somatostatin.- Molecular Model of Somatostatin Action.- Regulation of Somatostatin Secretion and Gene Expression.- Physiological Significance of Somatostatin.- Somatostatin in Disease.- References.- Somatostatin Receptors in the Central Nervous System.- Somatostatin Receptors.- Somatostatin Receptors in Pathology.- Conclusion.- References.- Somatostatin in Neuropsychiatric Disorders.- Neuropsychiatric Disease-Related Alterations.- Central Nervous System Effects of Somatostatin.- Somatostatin in Affective Disorder: Clinical Relevance.- Endocrine Correlates.- Role in Seizure Disorders and Effects of Psychopharmacological Agents..- Conclusions.- References.- The Physiological Role of Somatostatin in the Regulation of Nutrient Homeostasis.- Release of Somatostatin.- Mechanisms of Somatostatin Release.- Physiological Effects of Somatostatin.- Somatostatin and Nutrient Entry into the Circulation.- References.- Therapeutic Use of Somatostatin and Octreotide Acetate in Neuroendocrine Tumors.- Pharmacology of Octreotide Acetate.- The Effects of Somatostatin and Octreotide on the Pituitary.- The Effects of Somatostatin and Octreotide on Neuroendocrine Tumors of the Gut.- Unresolved Issues.- References.

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