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OverviewThis book provides the basis for understanding the elastic properties of nucleic acids (DNA, RNA), the methods used to manipulate them (e.g. optical, magnetic and acoustic tweezers and traps), and how to observe their interactions with proteins (e.g. fluorescence microscopy, FCS, FRET, etc.). It then exemplifies the use of these various methods in the study of three families of DNA enzymes: polymerases, helicases and topoisomerases. The book aims not to be exhaustive, but rather to stimulate the imagination of readers in the application of these single molecule approaches to the study of DNA/RNA and their interactions. Full Product DetailsAuthor: David Bensimon (Research Director and Professor, Research Director and Professor, LPS-ENS, PSL, CNRS and Department of Chemistry and Biochemistry, UCLA, USA) , Vincent Croquette (Research Director, Research Director, LPS-ENS, PSL, CNRS, France) , Jean-François Allemand (Professor, Professor, LPS-ENS, PSL, CNRS, France) , Xavier Michalet (Researcher, Researcher, Department of Chemistry and Biochemistry, UCLA, USA)Publisher: Oxford University Press Imprint: Oxford University Press Dimensions: Width: 17.80cm , Height: 1.70cm , Length: 24.90cm Weight: 0.614kg ISBN: 9780198530923ISBN 10: 0198530927 Pages: 240 Publication Date: 26 December 2018 Audience: College/higher education , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Active Availability: To order  Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us. Table of Contents1: Introduction to DNA 2: Manipulating DNA 3: Fluorescence Spectroscopy and Microscopy Techniques 4: The Mechanical Properties of Nucleic Acids 5: Structural Transitions in DNA 6: Single Molecule Studies of DNA-associated Motors 7: DNA and RNA Polymerases 8: DNA Helicases 9: Topoisomerases 10: ConclusionsReviewsthis book is helpful for different audiences... The volume is very well written and enjoyable to read. * Robert Ros, The Quarterly Review of Biology * Author InformationDavid Bensimon and Vincent Croquette have been co-leaders of a group at the LPS-ENS that has been studying single DNA molecules and their interactions with proteins since 1991. Jean-François Allemand, Terence Strick and Xavier Michalet have been their students and collaborators ever since. They have jointly developed magnetic traps and have been studying various aspects of single molecule DNA/protein transactions. Since joining the lab of Professor S. Weiss at UCLA , Xavier Michalet has been focusing on the use of fluorescent and spectroscopic methods to study single biomolecules. Tab Content 6Author Website:Countries AvailableAll regions |
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