Overview

Teachingagraduatecourseonsignaltransductioninthefallof2007wasvery enjoyable. Eachweek,mystudentsandIdiscussedarecentlypublishedresearch paperinsomeareaofsignaling,arguedabouttheappropriatenessofthemethod- ogyusedintheresearch,thedesignoftheexperiments,andwhethertheconc- sions drawn were supported bythe results presented. Finally, each student was askedtolistwhatwasgoodandwhatwasde?cientinthepaperandwhethershe/he wouldhaveacceptedorrejectedithadshe/herevieweditforpublication. Fora goodnumberofrecentpapers,aconsistentcomplaintofthestudentswasthatthe backgroundtotheresearchwasnotadequatelydescribed. Itcanofcoursebeargued that students should research the background. Either way, the need for a good sourceofbackgroundmaterialinordertoappreciatetheresearchpresentedina paperbecameapparenttomeandwastheinspirationfordevelopingthisbook. Thegoalinbringingthisbookwastoprovidestudentswithareviewofrecent developmentsinspeci?careasofcurrentinterestinsignaltransduction,suf?ciently indepthtomakerecentresearchpublicationsaccessible. However,giventhewide rangeofresearchtopicsbeinginvestigatedtodayinsignaling,achoicehadtobe madetofocusonaselectfew. Thischoicewasmadenotonlykeepingthecurrent research interest in mind, but also with the anticipation that these areas will continuetobeofinterestoverthenextseveralyears. Inchoosingpapersfordiscussioninmyclass,Ilookforhealth-relatednessofthe research,andthatisre?ectedinthelistofthebroadareascoveredinthisbook-G proteincoupledreceptors,growthfactors,nuclearreceptors,reactiveoxygenand nitrogenspecies,cellcycleandcancer;theemphasishasbeenonareasofsignaling researchwithimmediateclinicalsigni?cance. Ibelievethisbookwillservewellas supplementalreadingmaterialforundergraduateandgraduatestudentswithsimilar interest. Anotherareacoveredinthisbook,onenotoftenhighlightedinsignaltransd- tionbooks,isthatofsignalingplatforms,whichisemergingasasigni?cantareaof researchrelevanttocellularmetabolism,cellproliferation,differentiation,apop- sis,neurodegenerativediseases,andcancer. Theauthorscontributingtothisbook vii viii Preface areexpertsandactivecontributorstoresearchintheirspeci?careasofsignaling. I would like to thank them for their contributions and their suggestions in the developmentofthebook. IwouldliketoacknowledgethehelpofFrankTedeschi, astudentinmydepartment,whoassistedineditingthemanuscriptsandinprep- ingtheindex. IwouldalsoliketothankDr. SabineSchwarz,LifeSciencesEditorat SpringerVerlag,andDr. JuttaLindenbornwhohavebeenveryhelpfulatevery stageofproductionofthisbook. AriSitaramayya Contents PartI GProteinsandGProtein-Teachingagraduatecourseonsignaltransductioninthefallof2007wasvery enjoyable. Eachweek,mystudentsandIdiscussedarecentlypublishedresearch paperinsomeareaofsignaling,arguedabouttheappropriatenessofthemethod- ogyusedintheresearch,thedesignoftheexperiments,andwhethertheconc- sions drawn were supported bythe results presented. Finally, each student was askedtolistwhatwasgoodandwhatwasde?cientinthepaperandwhethershe/he wouldhaveacceptedorrejectedithadshe/herevieweditforpublication. Fora goodnumberofrecentpapers,aconsistentcomplaintofthestudentswasthatthe backgroundtotheresearchwasnotadequatelydescribed. Itcanofcoursebeargued that students should research the background. Either way, the need for a good sourceofbackgroundmaterialinordertoappreciatetheresearchpresentedina paperbecameapparenttomeandwastheinspirationfordevelopingthisbook. Thegoalinbringingthisbookwastoprovidestudentswithareviewofrecent developmentsinspeci?careasofcurrentinterestinsignaltransduction,suf?ciently indepthtomakerecentresearchpublicationsaccessible. However,giventhewide rangeofresearchtopicsbeinginvestigatedtodayinsignaling,achoicehadtobe madetofocusonaselectfew. Thischoicewasmadenotonlykeepingthecurrent research interest in mind, but also with the anticipation that these areas will continuetobeofinterestoverthenextseveralyears. Inchoosingpapersfordiscussioninmyclass,Ilookforhealth-relatednessofthe research,andthatisre?ectedinthelistofthebroadareascoveredinthisbook-G proteincoupledreceptors,growthfactors,nuclearreceptors,reactiveoxygenand nitrogenspecies,cellcycleandcancer;theemphasishasbeenonareasofsignaling researchwithimmediateclinicalsigni?cance. Ibelievethisbookwillservewellas supplementalreadingmaterialforundergraduateandgraduatestudentswithsimilar interest. Anotherareacoveredinthisbook,onenotoftenhighlightedinsignaltransd- tionbooks,isthatofsignalingplatforms,whichisemergingasasigni?cantareaof researchrelevanttocellularmetabolism,cellproliferation,differentiation,apop- sis,neurodegenerativediseases,andcancer. Theauthorscontributingtothisbook vii viii Preface areexpertsandactivecontributorstoresearchintheirspeci?careasofsignaling. I would like to thank them for their contributions and their suggestions in the developmentofthebook. IwouldliketoacknowledgethehelpofFrankTedeschi, astudentinmydepartment,whoassistedineditingthemanuscriptsandinprep- ingtheindex. IwouldalsoliketothankDr. SabineSchwarz,LifeSciencesEditorat SpringerVerlag,andDr. JuttaLindenbornwhohavebeenveryhelpfulatevery stageofproductionofthisbook. AriSitaramayya Contents PartI GProteinsandGProtein-CoupledReceptors 1 TraditionalGPCRPharmacologyandBeyond...3 AnnetteGilchristandMariaR. Mazzoni 2 RegulationofIntraneuronalTraf?ckingofG-Protein-Coupled ReceptorsbyNeurotransmittersInVivo ...25 Ve'roniqueBernard 3 SmallGTPasesandTheirRoleinRegulatingGProtein-Coupled ReceptorSignalTransduction ...43 FabiolaM. RibeiroandStephenS. G. Ferguson 4 RegulationofGProteinReceptorCoupling,MoodDisorders andMechanismofActionofAntidepressants ...63 MoranGolan,GabrielSchreiber,andSo?aAvissar 5 DysregulationofGProtein-CoupledReceptorSignaling inCancer ...83 JoAnnTrejo PartII GrowthFactors 6 InsulinSignalinginNormalandDiabeticConditions ...1 01 PatriceEFort,HisanoriImai,RajuRajala,andThomasW. Gardner 7 EpidermalGrowthFactor(EGF)ReceptorSignaling andCancer ...119 ElizabethS. HensonandSpencerB. Gibson ix x Contents 8 LeptinSignalingPathway...143 HiroyukiShimizu 9 SignalinginNormalandPathologicalAngiogenesis...159 MichaelR. MancusoandCalvinJ. Kuo PartIII SignalingPlatforms 10 SpatialandTemporalControlofCellSignaling byA-KinaseAnchoringProteins...183 F. DonelsonSmith,LoreneK. Langeberg,andJohnD. Scott 11 Mitochondria,aPlatformforDiverseSignalingPathways ...199 AstridC. SchaussandHeidiM. McBridee 12 Mitogen-ActivatedProteinKinases andTheirScaffoldingProteins ...219 DannyN. DhanasekaranandE. PremkumarReddy 2p 13 MolecularandFunctionalDeterminantsofCa SignalingMicrodomains ...237 InduS. Ambudkar,HweiL. Ong,andBrijB. Singh PartIV NuclearReceptors/Transcription 14 EukaryoticGeneTranscription ...257 JenniferH. GromekandArikDvir 15 EstrogenSignalingMechanisms...273 DapengZhangandVanceL. Trudeau 16 SignalTransductionPathwaysInvolved inGlucocorticoidActions ...289 PeterJ. Barnes PartV ReactiveSignalingMolecules 17 CellularSignalingbyReactiveOxygenSpecies:Biochemical BasisandPhysiologicalScope ...313 ' MichelB. Toledano,SimonFourquet,andBeno?tD'G proteincoupledreceptors,growthfactors,nuclearreceptors,reactiveoxygenand nitrogenspecies,cellcycleandcancer;theemphasishasbeenonareasofsignaling researchwithimmediateclinicalsigni?cance. Ibelievethisbookwillservewellas supplementalreadingmaterialforundergraduateandgraduatestudentswithsimilar interest. Anotherareacoveredinthisbook,onenotoftenhighlightedinsignaltransd- tionbooks,isthatofsignalingplatforms,whichisemergingasasigni?cantareaof researchrelevanttocellularmetabolism,cellproliferation,differentiation,apop- sis,neurodegenerativediseases,andcancer. Theauthorscontributingtothisbook vii viii Preface areexpertsandactivecontributorstoresearchintheirspeci?careasofsignaling. I would like to thank them for their contributions and their suggestions in the developmentofthebook. IwouldliketoacknowledgethehelpofFrankTedeschi, astudentinmydepartment,whoassistedineditingthemanuscriptsandinprep- ingtheindex. IwouldalsoliketothankDr. SabineSchwarz,LifeSciencesEditorat SpringerVerlag,andDr. JuttaLindenbornwhohavebeenveryhelpfulatevery stageofproductionofthisbook. AriSitaramayya Contents PartI GProteinsandGProtein-CoupledReceptors 1 TraditionalGPCRPharmacologyandBeyond...3 AnnetteGilchristandMariaR. Mazzoni 2 RegulationofIntraneuronalTraf?ckingofG-Protein-Coupled ReceptorsbyNeurotransmittersInVivo ...25 Ve'roniqueBernard 3 SmallGTPasesandTheirRoleinRegulatingGProtein-Coupled ReceptorSignalTransduction ...43 FabiolaM. RibeiroandStephenS. G. Ferguson 4 RegulationofGProteinReceptorCoupling,MoodDisorders andMechanismofActionofAntidepressants ...63 MoranGolan,GabrielSchreiber,andSo?aAvissar 5 DysregulationofGProtein-CoupledReceptorSignaling inCancer ...83 JoAnnTrejo PartII GrowthFactors 6 InsulinSignalinginNormalandDiabeticConditions ...101 PatriceEFort,HisanoriImai,RajuRajala,andThomasW. Gardner 7 EpidermalGrowthFactor(EGF)ReceptorSignaling andCancer ...119 ElizabethS. HensonandSpencerB. Gibson ix x Contents 8 LeptinSignalingPathway...143 HiroyukiShimizu 9 SignalinginNormalandPathologicalAngiogenesis...159 MichaelR. MancusoandCalvinJ. Kuo PartIII SignalingPlatforms 10 SpatialandTemporalControlofCellSignaling byA-KinaseAnchoringProteins...183 F. DonelsonSmith,LoreneK. Langeberg,andJohnD. Scott 11 Mitochondria,aPlatformforDiverseSignalingPathways ...199 AstridC. SchaussandHeidiM. McBridee 12 Mitogen-ActivatedProteinKinases andTheirScaffoldingProteins ...219 DannyN. DhanasekaranandE. PremkumarReddy 2p 13 MolecularandFunctionalDeterminantsofCa SignalingMicrodomains ...237 InduS. Ambudkar,HweiL. Ong,andBrijB. Singh PartIV NuclearReceptors/Transcription 14 EukaryoticGeneTranscription ...257 JenniferH. GromekandArikDvir 15 EstrogenSignalingMechanisms...273 DapengZhangandVanceL. Trudeau 16 SignalTransductionPathwaysInvolved inGlucocorticoidActions ...289 PeterJ. Barnes PartV ReactiveSignalingMolecules 17 CellularSignalingbyReactiveOxygenSpecies:Biochemical BasisandPhysiologicalScope ...313 ' MichelB. Toledano,SimonFourquet,andBeno?tD'Autreaux 18 SolubleGuanylylCyclase:TheNitricOxideReceptor...337 DorisKoeslingandAriSitaramayya Contents xi PartVI CellCycle,CellDeathandCancer 19 DistinctRolesofthePocketProteinsintheControl ofCellCycle...353 ParaskeviVogiatziandPierPaoloClaudio 20 Activationofthep53TumorSuppressoranditsMultipleRoles inCellCycleandApoptosis...375 LucianaE. GionoandJamesJ. Manfredi 21 AgingandCancer:CaretakersandGatekeepers ...3 97 DianavanHeemst 22 SignalTransductioninEmbryonicStemCells andtheRiseofiPSCells ...

Full Product Details

Author:   Ari Sitaramayya
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2010 ed.
Dimensions:   Width: 15.60cm , Height: 2.50cm , Length: 23.40cm
Weight:   0.923kg
ISBN:  

9783642021114

ISBN 10:   3642021115
Pages:   437
Publication Date:   26 November 2009
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

G Proteins and G Protein-Coupled Receptors.- Traditional GPCR Pharmacology and Beyond.- Regulation of Intraneuronal Trafficking of G-Protein-Coupled Receptors by Neurotransmitters In Vivo.- Small GTPases and Their Role in Regulating G Protein-Coupled Receptor Signal Transduction.- Regulation of G Protein Receptor Coupling, Mood Disorders and Mechanism of Action of Antidepressants.- Dysregulation of G Protein-Coupled Receptor Signaling in Cancer.- Growth Factors.- Insulin Signaling in Normal and Diabetic Conditions.- Epidermal Growth Factor (EGF) Receptor Signaling and Cancer.- Leptin Signaling Pathway.- Signaling in Normal and Pathological Angiogenesis.- Signaling Platforms.- Spatial and Temporal Control of Cell Signaling by A-Kinase Anchoring Proteins.- Mitochondria, a Platform for Diverse Signaling Pathways.- Mitogen-Activated Protein Kinases and Their Scaffolding Proteins.- Molecular and Functional Determinants of Ca2+ Signaling Microdomains.- Nuclear Receptors / Transcription.- Eukaryotic Gene Transcription.- Estrogen Signaling Mechanisms.- Signal Transduction Pathways Involved in Glucocorticoid Actions.- Reactive Signaling Molecules.- Cellular Signaling by Reactive Oxygen Species: Biochemical Basis and Physiological Scope.- Soluble Guanylyl Cyclase: The Nitric Oxide Receptor.- Cell Cycle, Cell Death and Cancer.- Distinct Roles of the Pocket Proteins in the Control of Cell Cycle.- Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis.- Aging and Cancer: Caretakers and Gatekeepers.- Signal Transduction in Embryonic Stem Cells and the Rise of iPS Cells.- Erratum to.

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