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OverviewOver the last 30 years, our understanding of a receptors has undergone a colossal evolution. They began as theoretical entities, then progressed to enigmatic receptors, and finally to identified proteins with important biological functions. Since the first book on a receptors was published in 1994, there have been many significant advances in the field. We now know that o receptors subserve many critical functions in the body and recent studies indicate that they are promising drug development targets for a host of neurological, psychiatric, cardiovascular, ophthalmological, immunological, and gastrointestinal disorders. This book provides a timely update on the medicinal chemistry, cell biology, and clinical implications of a receptors. It puts the information in a historical perspective to help new comers to the field successfully navigate the confusing early history surrounding these proteins, and it provides a launching point from which future studies and research directions can easily be developed. The full impact of a receptors on biological function has yet to be determined. The existing gaps in our knowledge base offer untold opportunities for future research. It is our hope that the information contained in this book will stimulate new, exciting research on a receptors and ultimately lead to innovative insights into basic biological mechanisms and novel therapeutic advances. Full Product DetailsAuthor: Rae R. Matsumoto , Wayne D. Bowen , Tsung Ping SuPublisher: Springer-Verlag New York Inc. Imprint: Springer-Verlag New York Inc. Edition: 2007 ed. Dimensions: Width: 15.50cm , Height: 2.20cm , Length: 23.50cm Weight: 0.652kg ISBN: 9781489988683ISBN 10: 1489988688 Pages: 413 Publication Date: 16 November 2014 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of Contents? Receptors: Historical Perspective and Background.- Medicinal Chemistry: New Chemical Classes and Subtype-Selective Ligands.- Irreversible ? Compounds.- Pharmacophore Models for ?1 Receptor Binding.- Cloning of ?1 Receptor and Structural Analysis of Its Gene and Promoter Region.- Site-Directed Mutagenesis.- ? Receptor Modulation of Ion Channels.- Subcellular Localization and Interacellular Dynamics of ?1 Receptors.- Intracellular Signaling and Synaptic Plasticity.- Modulation of Classical Neurotransmitter Systems by ? Receptors.- ?2 Receptors: Regulation of Cell Growth and Implications for Cancer Diagnosis and Therapeutics.- Cognitive Effects of ? Receptor Ligands.- ? Receptors and Scizophrenia.- Potential Role of ? Ligands and Neurosteroids in Major Depression.- ? Receptors and Drug Abuse.- ?1 Receptors and the Modulation of Opiate Analgesics.- ? Receptors in the Immune System: Implications for Potential Therapeutic Intervention - An Overview.- ? Receptors and Gastrointestinal Function.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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