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OverviewScientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians. Full Product DetailsAuthor: Committee on Developmental Toxicology , Board on Environmental Studies and Toxicology , Commission on Life Sciences , Division on Earth and Life StudiesPublisher: National Academies Press Imprint: National Academies Press ISBN: 9780309070867ISBN 10: 0309070864 Pages: 354 Publication Date: 21 November 2000 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: To order  Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us. Table of ContentsList of Abbreviations; Executive Summary; 1 Introduction; Background; Recent Advances in Developmental Biology and the Promise of Genomics; Committee's Approach to Its Charge; Organization of the Report; 2 Developmental Defects and Their Causes; Toxicant Exposure and Developmental Defects; The Chemical Universe; Summary; 3 Current Practices for Assessing Risk for Developmental Defects and Their Limitations; The Developmental Toxicity Risk Assessment Process; Biomarkers; Limitations in Developmental Toxicity Risk Assessments; Summary; 4 Mechanisms of Developmental Toxicity; History of Developmental Toxicology: Growth of a New Field; Principles of Teratology; Mechanisms of Toxicity; Summary; 5 Human Genetics and the Human Genome Project; Genotype, Phenotype, and Multifactorial Inheritance; Polymorphisms; The Human Genome Project; Recent Developments in Molecular Epidemiology; Summary; 6 Recent Advances in Developmental Biology; A Brief History of Developmental Biology; Advances in Developmental Biology; Summary; 7 Using Model Animals to Assess and Understand Developmental Toxicity; Model Organisms and the Genetic Approach; The Major Model Animals for Genetic Analysis; Possible Applications of Model Animal Research to Developmental Toxicology; Gene Expression as Determined by In Vitro and Engineered Cell Technologies; Summary; 8 A Multilevel Approach to Improving Risk; Assessment for Developmental Toxicity; The Multidisciplinary, Multilevel Interactive Approach; Summary; 9 Conclusions and Recommendations; Conclusions in Relation to the Charge; Recommendations; References; Appendix A: Glossary; Appendix B: Database Descriptions; Appendix C: Signaling Pathways; Appendix D: Biographical Information on the Committee on Developmental Toxicology; IndexReviewsAuthor InformationCommittee on Developmental Toxicology, Board on Environmental Studies and Toxicology, National Research Council Tab Content 6Author Website:Countries AvailableAll regions |
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