Overview

V dannoy rabote vypolnen analiz svoystv osnovnykh tipov povtoryayushchikhsya posledovatel'nostey genomov yadra/organell eukariot (nukleoida prokariot), soglasno kotoromu korotkie/dlinnye povtory igrayut real'nuyu/potentsial'nuyu roli v bol'shinstve, esli ne vo vsekh, molekulyarno-geneticheskikh sobytiyakh, i, veroyatno, podvergayutsya preobrazovaniyam tipa povtor1→povtor2/modifitsirovannyy-povtor1 s peremeshcheniem ikh (i flankiruemykh/svyazannykh s nimi posledovatel'nostey) vnutri/mezhdu nekodiruyushchey i kodiruyushchey oblastyami genoma za evolyutsionno znachimyy promezhutok vremeni. Takoy geneticheskiy poisk mozhet privodit' k konsolidiruemym sobytiyam adaptatsii, komodifikatsii razlichnykh uchastkov genoma, letalyam i patologiyam (neyrologicheskim, onkologicheskim, geneticheskim, dr.). Intriguyushchey yavlyaetsya vozmozhnost', chto povtory, proiskhozhdenie kotorykh (i, inogda, razmnozhenie) vo mnogom ne yasny, sami mogut vosproizvodit'sya otdel'nym ot genoma i, veroyatno, evolyutsionno bolee drevnim, chem sovremennye yadernye genomy, gipoteticheskim mekhanizmom, pri kotorom formiruyutsya mini/mikrosatellit-podobnye povtoryayushchiesya (inogda unikal'nye) posledovatel'nosti. Takoy mekhanizm nazyvaetsya variabel'naya Poepitopnaya Obratnaya Translyatsiya.

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