Overview

James Gray and Ulrich Desselberger have assembled a comprehensive collection of established and cutting-edge methods for studying and illuminating the structure, molecular biology, pathogenesis, epidemiology, and prevention in animal models of infection with rotaviruses, an important cause of infant morbidity and mortality. Presented by experts in the fields of animal and human rotavirus infections and rotavirus vaccine research, these readily reproducible methods detail molecular and other modern techniques, and include relevant background information and various notes to ensure reproducible and robust results. Authoritative and up-to-date, Rotaviruses: Methods and Protocols offers researchers today's benchmark compendium of experimental methods for the investigation of this medically significant virus.

Full Product Details

Author:   James Gray ,  Ulrich Desselberger
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   Softcover reprint of hardcover 1st ed. 2000
Volume:   34
Dimensions:   Width: 15.20cm , Height: 1.50cm , Length: 22.90cm
Weight:   0.410kg
ISBN:  

9781617371608

ISBN 10:   1617371602
Pages:   262
Publication Date:   09 November 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Rotaviruses: Basic Facts.- Electron Cryomicroscopy and Computer Image Processing Techniques.- Virus Replication.- Rotavirus Entry into Tissue Culture Cells.- Mixed Infections with Rotaviruses.- Pathogenesis and Animal Models.- Immunologic Methods and Correlates of Protection.- In Vivo Study of Immunity to Rotaviruses.- Evaluation of Rotavirus Vaccines in Small Animal Models.- Methods of Rotavirus Detection, Sero- and Genotyping, Sequencing, and Phylogenetic Analysis.- Epidemiology of Group A Rotaviruses Surveillance and Burden of Disease Studies.- Future Rotavirus Research.

Reviews

This book will be very useful to both new investigators in the field and persons who have a general interest in rotaviruses and the methods to be used in their study. Many chapter contributors also provide very useful summaries of the methods used in a specific aspect of rotavirus research. These will be helpful to even the most experienced investigator in the field. -Doody's Health Sciences Book Review Journal This book has no recent equivalent...The book will not only be profitable for the RV specialist; people interested in other viruses or cellular physiology will surely benefit from the lessons learned from studies of RV electron cryomicroscopy, RV replication or animal models of RV infections. - Trends in Microbiology ...methods, which have proven invaluable to studies, are given in detail in this excellent new book. The contributors have written detailed protocols for, predominantly, molecular and serological methods with emphases on those that are somewhat unique to rotavirus research...However, there is much more to this book than the highly detailed protocols...The last of the central chapters is by Mary Ramsay and David Brown and describes the epidemiology of rotavirus infections and concentrates on surveillance and disease burden. Anyone still unconvinced of the need for a rotavirus vaccine should read this chapter. -J. Med. Microbiol This high quality compendium comprises 12 concise chapters, each presented in the same easy to follow layout...this book at $89.50 is reasonable value and an essential reference for any laboratory undertaking rotavirus research. - Microbiology Today

This book will be very useful to both new investigators in the field and persons who have a general interest in rotaviruses and the methods to be used in their study. Many chapter contributors also provide very useful summaries of the methods used in a specific aspect of rotavirus research. These will be helpful to even the most experienced investigator in the field. -Doody's Health Sciences Book Review Journal This book has no recent equivalent....The book will not only be profitable for the RV specialist; people interested in other viruses or cellular physiology will surely benefit from the lessons learned from studies of RV electron cryomicroscopy, RV replication or animal models of RV infections. - Trends in Microbiology ...methods, which have proven invaluable to studies, are given in detail in this excellent new book. The contributors have written detailed protocols for, predominantly, molecular and serological methods with emphases on those that are somewhat unique to rotavirus research....However, there is much more to this book than the highly detailed protocols....The last of the central chapters is by Mary Ramsay and David Brown and describes the epidemiology of rotavirus infections and concentrates on surveillance and disease burden. Anyone still unconvinced of the need for a rotavirus vaccine should read this chapter. -J. Med. Microbiol This high quality compendium comprises 12 concise chapters, each presented in the same easy to follow layout....this book at $89.50 is reasonable value and an essential reference for any laboratory undertaking rotavirus research. - Microbiology Today

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