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OverviewAs was shown in the literature over the years Notch pathway was reported to play an essential role in the pathogenesis of T-ALL. However, most studies concentrated on the role of Notch1 owing to the discovery of several mutations which are present in > 50% of T-ALL cases. On the other hand a controversy was reported regarding the role of Notch3 in T-ALL where some authors reported its pivotal role in T-ALL while others dismissed its role due to the absence of mutations in this gene. Thus in this work our aim was to study the expression of the main genes involved in the Notch pathway namely Notch1, Notch3, Hes1 and the gene encoding pT alpha, to verify the role of Notch1 versus Notch3 in the pathogenesis of T-ALL and to correlate the level of the expression of such genes to other prognostic parameters. We also wanted to compare children to adults as ALL constitutes two different pathological entities in the two age groups Full Product DetailsAuthor: Eman RadwanPublisher: LAP Lambert Academic Publishing Imprint: LAP Lambert Academic Publishing Dimensions: Width: 15.20cm , Height: 1.70cm , Length: 22.90cm Weight: 0.426kg ISBN: 9783659374227ISBN 10: 3659374229 Pages: 288 Publication Date: 06 May 2013 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In stock We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |