Overview

Nitric Oxide (NO) is a free radical, a gas, and a pluripotent product of mammalian cells. Only a few years ago, scientific discussions of NO were largely held in the context of the chemistry of air pollution. Now, however, the great significance of NO as a signalling and cytotoxic molecule has captured the attention of the biomedical community. This book provides a very up-to-date review of the role of NO in sepsis and ARDS. Consideration is given to NO both as a pathophysiologic mediator as well as a therapeutic agent. An internationally recognized group of scientists and clinicians have contributed chapters dealing with cutting-edge science and practical clinical strategies. Numerous tables and charts have been included to aid the reader in understanding this fascinating and important subject.

Full Product Details

Author:   M.P. Fink ,  D. Payen
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1995
Volume:   24
Dimensions:   Width: 15.50cm , Height: 2.30cm , Length: 23.50cm
Weight:   0.674kg
ISBN:  

9783642799228

ISBN 10:   3642799221
Pages:   430
Publication Date:   21 December 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Biochemistry of Nitric Oxide and Regulation of Gene Expression.- Biosynthesis of Nitric Oxide: An Overview.- Biochemistry and Synthesis of NO in Sepsis.- Effect of Hypoxia on Inducible Nitric Oxide Synthase (iNOS) in Renal Mesangial Cells.- Vascular Smooth Muscle Function under Conditions of Sepsis and Endotoxemia.- Nitric Oxide as a Mediator in Gram-Positive Sepsis.- Effects of Nitric Oxide on various Cell Types and Organs.- Nitric Oxide and the Heart in Sepsis.- Influence of Nitric Oxide on Cardiac Systolic and Diastolic Function.- Cellular Actions of Nitric Oxide on the Circulatory System.- Role of Nitric Oxide in Cerebral Ischemia.- Platelet Regulation and Damage in Vascular Thrombotic and Septic Disorders.- Nitric Oxide as a Mediator of Hypotension and Inflammation in Sepsis.- Effect of Nitric Oxide on Intestinal Epithelial Structure and Function.- Nitric Oxide in Shock.- Inhibition of Nitric Oxide Synthase Activity in Circulatory Shock: Friend or Foe?.- Use of Nitric Oxide Synthase Inhibitors to reverse Hyperdynamic Circulation and MOF.- Cardiovascular Alterations associated with Interleukin-2 Therapy.- Blocking the Effects of Nitric Oxide in Septic Shock.- Inhibition of Nitric Oxide Production in Clinical Septic Shock.- Nitric Oxide and the Lung.- Role of Nitric Oxide in Pulmonary Vascular Dysfunction.- Endogenous Nitric Oxide Formation in the Respiratory System.- Pulmonary Vascular Regulation by Endogenous Nitric Oxide.- Nitric Oxide Inhalation in RDS and ARDS.- Inhaled Nitric Oxide: A Review.- Monitoring and Safety of Inhaled Nitric Oxide.- Persistent Pulmonary Hypertension of the Newborn.- Almitrine and Inhaled Nitric Oxide in Acute Respiratory Failure.- Nitric Oxide Inhalation in ARDS.- Inhaled Nitric Oxide: The Light and Shadow of a Therapeutic Breakthrough.

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