Overview

In view of the numerous failures of clinical trials aimed at improving stroke therapy, the role and potential benefit of experimentally modeling focal cerebral ischemia in rodents has been debated. When methods of systematic review and metaanalyis are applied, however, it turns out that experimental models actually faithfully predicted the negative outcomes of clinical trials. In addition, thrombolysis and neuroprotection by hypothermia, first described in animal models, are key examples of treatment modalities that have made it successfully into clinical practice. In Rodent Models of Stroke, an international consortium of authors aims at critically addressing the issues on a very practical level, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. The structure and content of the book reflect both the authors’ longstanding expertise in experimental and clinical stroke research and their roles in training the scientific community in the tools of the trade. As a volume in the successful Neuromethods series, the chapters provide authoritative reviews of the most commonly used, well-honed approaches in the field today. Stimulating and easy-to-use, Rodent Models of Stroke will help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments.

Full Product Details

Author:   Ulrich Dirnagl
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   Softcover reprint of the original 1st ed. 2010
Volume:   47
Weight:   0.574kg
ISBN:  

9781493958078

ISBN 10:   1493958070
Pages:   286
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

From Bedside to Bench: How Clinical Reality Should Instruct Stroke Modeling.- How to Avoid Bumping into the Translational Roadblock.- Modeling Focal Cerebral Ischemia in Rodents: Introduction and Overview.- Focal Cerebral Ischemia in the Mouse and Rat Using the Intraluminal Suture–Filament Model.- Focal Ischemia Models: Middle Cerebral Artery Occlusion Induced by Electrocoagulation, Occluding Devices, and Endothelin-1.- Rodent Models of Thromboembolic Stroke.- Photochemical and Endothelin Models of Focal Brain Ischemia.- Housing in an Enriched Environment: A Tool to Study Functional Recovery After Experimental Stroke.- Modeling Risk Factors and Confounding Effects in Stroke.- Effect of Anesthesia in Stroke Models.- Noninvasive Brain Imaging in Small Animal Stroke Models: MRI and PET.- Non-invasive Optical Imaging in Small Animal Models of Stroke.- Behavioral Testing in Mouse Models of Stroke.- Behavioral Testing in Rodent Models of Stroke.- Histology and Infarct Volume Determination.- Ethics of Modeling of Cerebral Ischemia in Small Animals.- Quality Control and Standard Operating Procedures.- Statistics in Experimental Stroke Research: From Sample Size Calculation to Data Description and Significance Testing.- Complexities, Confounders, and Challenges in Experimental Stroke Research: A Checklist for Researchers and Reviewers.

Reviews

From the reviews: Rodent Models of Stroke by U. Dirnagl is simply the best ischemia book on principles, theory, protocols, and techniques which has been written over the past 25 years. ... This book is aimed at a broad audience on ischemia research including graduate students, postgraduate scholars, junior faculty, and senior seasoned investigators. ... In short, this is an ideal textbook for being a primer or a detailed reference to refer to. I highly recommend it. (Joseph J. Grenier, Amazon.com, September, 2013)

From the reviews: “Rodent Models of Stroke by U. Dirnagl is simply the best ischemia book on principles, theory, protocols, and techniques which has been written over the past 25 years. … This book is aimed at a broad audience on ischemia research including graduate students, postgraduate scholars, junior faculty, and senior seasoned investigators. … In short, this is an ideal textbook for being a primer or a detailed reference to refer to. I highly recommend it.” (Joseph J. Grenier, Amazon.com, September, 2013)

From the reviews: Rodent Models of Stroke by U. Dirnagl is simply the best ischemia book on principles, theory, protocols, and techniques which has been written over the past 25 years. ... This book is aimed at a broad audience on ischemia research including graduate students, postgraduate scholars, junior faculty, and senior seasoned investigators. ... In short, this is an ideal textbook for being a primer or a detailed reference to refer to. I highly recommend it. (Joseph J. Grenier, Amazon.com, September, 2013)

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions