Overview

Recent studies on the activities of RNA in the cell have revolutionized our understanding of the many roles played by this molecule. The first two editions of The RNA World (1993, 1999) shed light on the pre-biotic era dominated by this versatile molecule, and provided an overview of the state of RNA research at the time. The new third edition of The RNA World updates this perspective, describing the vast array of newly discovered roles for RNA in the modern world. The updated original chapters are supplemented with new chapters on RNA-protein complexes, snRNPs and snoRNPs, telomerase RNA, RNAi, microRNAs, noncoding RNA, and many other subjects. This book is essential reading for anyone interested in the biology of nucleic acids and gene regulation and a valuable resource for teaching these concepts.

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This is a big book, full of information. Although it is a compendium of chapters by different authors, it manages a surprisingly smooth flow and consistency of style...[It's] a good reference for anyone who wishes to begin to understand the diverse structures, functions and roles of RNA in cell biology. Nature Genetics As in previous editions of The RNA World, the third edition discusses the potential prebiotic roles of RNA and reviews understanding of the current RNA world. The main difference in this latest edition is that it considers the significantly expanded breadth of RNA function that we now know exists in the modern biosphere by including additional chapters on areas such as riboswitches, microRNAs and RNAi. A particularly pleasing feature of the new book is the diversity of scientific approaches covered, ranging from nucleic acid chemistry through structural biology, modeling and theoretical considerations, to single molecule studies. In summary, this comprehensive and stimulating compendium of reviews of RNA worlds past and present is an essential and enjoyable read for researchers and teachers with interests in the structure and function of nucleic acids and in gene expression. It is a recommended purchase for any research library as well as a wise buy for research groups working in related areas. Microbiology Today In summary, these chapters are comprehensive, well written, and will be an excellent reference for specialists in the field as well as a fine textbook for advanced graduate courses in RNA biology. I enthusiastically recommend this volume. The Quarterly Review of Biology

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