Overview

Developments over the past few years have revealed the remarkable versatility of RNA in any compartment of the cell, tasks that had been thought to be exclusively in the realm of proteins and even beyond. The chapters in this book written by leading investigators in the field provide insight into various promising avenues where RNA and nucleic acid derivatives including antisense RNAs, such as siRNA, miRNAs, amplification/selection (SELEX) generated aptamers as well as ribozymes are at the threshold of impacting medicine.

Full Product Details

Author:   Volker A. Erdmann ,  Jürgen Brosius ,  Jan Barciszewski
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of hardcover 1st ed. 2006
Volume:   173
Weight:   0.724kg
ISBN:  

9783642066030

ISBN 10:   3642066038
Pages:   464
Publication Date:   12 February 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Why RNA and DNA Have Different Structures.- Regulatory RNAs as Mediators of Virulence Gene Expression in Bacteria.- Regulatory RNAs in Mammals.- Aminoglycoside Interactions with RNAs and Nucleases.- High-Throughput RNA Interference in Functional Genomics.- Antiviral Applications of RNAi.- RNA Interference: Its Use as Antiviral Therapy.- Gene Silencing of Virus Replication by RNA Interference.- Progress in the Development of Nucleic Acid Therapeutics.- Screening and Determination of Gene Function Using Randomized Ribozyme and siRNA Libraries.- Ribozymes and siRNAs: From Structure to Preclinical Applications.- Strategies to Identify Potential Therapeutic Target Sites in RNA.- Oligonucleotide-Based Antiviral Strategies.- Gene-Expressed RNA as a Therapeutic: Issues to Consider, Using Ribozymes and Small Hairpin RNA as Specific Examples.- RNA Aptamers: From Basic Science Towards Therapy.- RNA Aptamers Directed Against Oligosaccharides.- Aptamer-Based Biosensors: Biomedical Applications.- Application of Aptamers in Therapeutics and for Small-Molecule Detection.- RNA Aptamers as Potential Pharmaceuticals Against Infections with African Trypanosomes.- RNA Targeting Using Peptide Nucleic Acid.- Locked Nucleic Acid: High-Affinity Targeting of Complementary RNA for RNomics.- Engineering RNA-Based Circuits.- Selection of RNase-Resistant RNAs.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions