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OverviewTo thrive, every living cell must continuously gauge and respond to changes in its environment. These changes are ultimately implemented by modulating gene expression, a process that relies on transcription by Nature’s most multivalent molecular machine, the RNA polymerase. This book covers progress made over the past decade understanding how this machine functions to compute the cellular state, from the atomistic structural level responsible for chemistry to the integrative level at which RNA polymerase interacts with the other key molecular machineries of the cell. Full Product DetailsAuthor: Robert Landick (University of Wisconsin, USA) , Terence Strick (Institut Jacques Monod, France) , Jue Wang (University of Wisconsin-Madison, USA) , Michelle WangPublisher: Royal Society of Chemistry Imprint: Royal Society of Chemistry Edition: 2nd edition Volume: Volume 19 Weight: 0.596kg ISBN: 9781788013659ISBN 10: 1788013654 Pages: 294 Publication Date: 15 December 2021 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsThe Transition from Transcription Initiation to Transcription Elongation: Start Site Selection, Initial Transcription, and Promoter Escape; Molecular Basis for Transcriptional Fidelity Control by RNA Polymerase II; 1RNA Polymerase as a Torsional Motor; RNA Polymerase-associated Transcription Elongation Factors; Rho Termination Factor: One Ring to Bind Them All; Global Regulation of Transcription by Nucleotides and (p)ppGpp; Helicases and the Obstructive RNAP; Transcription/Replication Conflicts, Resolution and Coregulation; Using Single-cell RNA Measurements to Decipher the Stochastic Kinetics of Transcription; Molecular Dynamics Simulations and Kinetic Network Models Elucidate RNA Polymerase Transcription Elongation MechanismsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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