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OverviewRibonucleic acid (RNA) is a macromolecule that plays a central role in cell physiology: RNA molecules act as intermediates between the deoxyribonucleic acid (DNA), where genetic information is stored, and proteins, which perform the necessary functions within the cell. Traditionally, the structural and functional properties of RNA are closely linked to gene expression. However, RNA-based enzymes, called ribozymes, are also involved in catalysis and small RNAs regulate key cellular processes, such as cell growth, division, differentiation, aging and death. RNA is a sensitive macromolecule that can be easily damaged by environmental conditions (ultraviolet radiation, oxidative stress) and biological factors (ribonucleases, ribotoxins, CRISPR-Cas systems). Therefore, cells have developed mechanisms to protect and/or repair RNA molecules. This book presents an overview of the biology of RNA damage, protection and repair in prokaryotes and eukaryotes. Individual chapters cover the expression regulation, enzymology and physiological role of such systems, and link them to important human diseases such as cancer and degenerative diseases. Full Product DetailsAuthor: Ioly Kotta-LoizouPublisher: Springer Nature Switzerland AG Imprint: Springer Nature Switzerland AG Edition: 1st ed. 2021 Weight: 0.296kg ISBN: 9783030765736ISBN 10: 3030765733 Pages: 178 Publication Date: 06 July 2022 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsBook Title: RNA Damage and Repair ToC Preface RNA Damage and Repair in Prokaryotes Chapter 1 - Endoribonucleases of the toxin-antitoxin systems induce abortive infection Yuichi Otsuka Chapter 2 - The lifecycle of ribosomal RNA in bacteria Maria Grazia Giuliano, Christoph Engl Chapter 3 - The Rtc RNA end healing and sealing system Danai Athina Irakleidi, Harry Beaven, Martin Buck, Ioly Kotta-Loizou RNA Damage and Repair in Eukaryotes Chapter 4 - Oxidative and nitrative RNA modifications in plants Jagna Chmielowska-Bąk, Karolina Izbiańska-Jankowska, Magdalena Arasimowicz-Jelonek, Joanna Deckert, Jolanta Floryszak-Wieczorek Chapter 5 - The role of ribonucleases in RNA damage, inactivation, and degradation Fabian Hia and Osamu Takeuchi Chapter 6 - Cytoplasmic mRNA recapping: An unexpected form of RNA repair Daniel R. Schoenberg RNA Damage in Human Diseases Chapter 7 - Adenosine-to-Inosine RNA editing: a key RNA processing step rewriting transcriptome in normal physiology and diseases Priyankaa Pitcheshwar, Haoqing Shen, Jian Han, Sze Jing Tang Chapter 8 - RNA-mediated metabolic defects in microsatellite expansion diseases Nan ZhangReviewsAuthor InformationAbout the Editor: Dr Ioly Kotta-Loizou is currently a Research Associate in the Department of Life Sciences, Imperial College London, UK. She is also a Visiting Lecturer at University of Hertfordshire and an Honorary Lecturer at University of Manchester. She holds a BSc in Biology, a MSc in Bioinformatics and a PhD in Molecular Microbiology from the University of Athens, Greece. Ioly has a keen interest in microorganisms and her studies focus on microbial life cycles and pathogenicity, together with potential applications in medicine and agriculture. Currently, she investigates RNA expression, damage and repair in bacteria, and how these processes can be linked to antibiotic resistance. In parallel, she explores how RNA viruses found in pathogenic fungi targeting humans, plants or insects can potentially be used in biological control. Ioly is a Fellow of the Higher Education Academy, and teaches next-generation sequencing and virology to undergraduate and postgraduate students. She is a member of the RNA Society, an Editor for the scientific journals Archives of Virology, Viruses, Pathogens, Microorganisms and Frontiers, and a Chair in the International Committee on Taxonomy of Viruses. Tab Content 6Author Website:Countries AvailableAll regions |
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