Overview

A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world.

Full Product Details

9781603277013

Table of Contents

Reviews

<p>From the reviews: <p><p> This book will appeal to medical students needing a detailed review of area . It is most suitable for libraries . The individual chapters are authoritative and comprehensive . a source for in-depth and specific information. (Mark Harris, Microbiology Today, November, 2006)

Author Information

Tab Content 6

Customer Reviews

Recent Reviews

Countries Available