Free Delivery Over $100
|
|
|||
|
||||
OverviewThe kidney is innervated with efferent sympathetic nerve fibers reaching the renal vasculature, the tubules, the juxtaglomerular granular cells, and the renal pelvic wall. The renal sensory nerves are mainly found in the renal pelvic wall. Increases in efferent renal sympathetic nerve activity reduce renal blood flow and urinary sodium excretion by activation of ?1-adrenoceptors and increase renin secretion rate by activation of ?1-adrenoceptors. In response to normal physiological stimulation, changes in efferent renal sympathetic nerve activity contribute importantly to homeostatic regulation of sodium and water balance. The renal mechanosensory nerves are activated by stretch of the renal pelvic tissue produced by increases in renal pelvic pressure of a magnitude that may occur during increased urine flow rate. Activation of the sensory nerves elicits an inhibitory renorenal reflex response consisting of decreases in efferent renal sympathetic nerve activity leading to natriuresis. Increasing efferent sympathetic nerve activity increases afferent renal nerve activity which, in turn, decreases efferent renal sympathetic nerve activity by activation of the renorenal reflexes. Thus, activation of the afferent renal nerves buffers changes in efferent renal sympathetic nerve activity in the overall goal of maintaining sodium balance. In pathological conditions of sodium retention, impairment of the inhibitory renorenal reflexes contributes to an inappropriately increased efferent renal sympathetic nerve activity in the presence of sodium retention. In states of renal disease or injury, there is a shift from inhibitory to excitatory reflexes originating in the kidney. Studies in essential hypertensive patients have shown that renal denervation results in long-term reduction in arterial pressure, suggesting an important role for the efferent and afferent renal nerves in hypertension. Full Product DetailsAuthor: Ulla Kopp , D. Neil Granger , Joey GrangerPublisher: Morgan & Claypool Publishers Imprint: Morgan & Claypool Publishers Dimensions: Width: 18.70cm , Height: 0.40cm , Length: 23.50cm Weight: 0.178kg ISBN: 9781615042319ISBN 10: 1615042318 Pages: 96 Publication Date: 30 December 2010 Audience: College/higher education , Professional and scholarly , Undergraduate , Postgraduate, Research & Scholarly Format: Paperback Publisher's Status: Active Availability: Awaiting stock  The supplier is currently out of stock of this item. It will be ordered for you and placed on backorder. Once it does come back in stock, we will ship it out for you. Table of ContentsPart I: Efferent Renal Sympathetic Nerves Introduction Neuroanatomy Neural Control of Renal Hemodynamics Neural Control of Renal Tubular Function Neural Control of Renin Secretion Rate Part II: Afferent Renal Sensory Nerves Introduction Neuroanatomy Renorenal Reflexes Mechanisms Involved in the Activation of Afferent Renal Sensory Nerves Part III: Pathophysiological States Efferent Renal Sympathetic Nerves Afferent Renal Sensory Nerves Conclusions ReferencesReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
||||
