Overview

The intention of the present monography is to shed more light on the regulation of Sertoli cell and germ cell differentiation. Involving knockout and transgenic mouse models, the authors focus on male factor infertility that might be related to altered maturation of Sertoli cells, male factor infertility that might be due to incorrect histone-to-protamine exchange in haploid spermatids, and progression of testicular germ cell cancer that might be favoured by an aberrant Sertoli cell germ cell communication.

Full Product Details

Author:   R. Brehm ,  Klaus Steger
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2005 ed.
Volume:   181
Dimensions:   Width: 15.50cm , Height: 0.60cm , Length: 23.50cm
Weight:   0.204kg
ISBN:  

9783540257509

ISBN 10:   3540257500
Pages:   95
Publication Date:   16 September 2005
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Spermatogenesis.- Organization of the seminiferous epithelium.- Synchronization of spermatogenesis.- Regulation of spermatogenesis.- The Sertoli cell.- Origin and maturation of the Sertoli cell.- Altered Sertoli cell differentiation in testicular disorders.- Differentiation markers of the Sertoli cell.- Sertoli cell intercellular communication.- Knockout and transgenic mouse models and mutations in man.- The differentiation of male germ cells.- The regulation of gene expression during prespermatogenesis.- The regulation of gene expression during spermatogenesis.- Idiopathic male infertility: impaired histone-to-protamine exchange?- Male infertility caused by incorrect transcriptional regulation.- Male infertility caused by incorrect translational regulation.- Male infertility caused by incorrect chromatin condensation.- Carcinoma-in-situ of the testis and testicular germ cell tumour: impaired intercellular communication due to altered Sertoli cell differentiation?- Carcinoma-in-situ of the testis and testicular germ cell tumour.- Sertoli cell differentiation in seminiferous tubules infiltrated with carcinoma-in-situ of the testis.- Role of gap junctional intercellular communication in carcinogenesis.- Role of gap junctional intercellular communication in the development of carcinoma-in-situ of the testis to testicular germ cell tumour.- References.- Subject index.

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