Overview

The use of molecular biology and biochemistry to study the regulation of gene expression has become a major feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental approaches used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. For example, it has been difficult to find appropriate texts that examine specific experimental goals, such as proving that an increased level of mRNA for a given gene is attributable to an increase in transcription rates. Regulation of Gene Expression: Molecular Mechanisms is intended to serve as either a textbook for graduate students or as a basic reference for laboratory personnel. Indeed, we are using this book to teach a graduate-level class at The Pennsylvania State University. For more details about this class, please visit http://moltox. cas. psu. edu and select “Courses. ” The goal for our work is to provide an overview of the various methods and approaches to characterize possible mechanisms of gene regulation. Further, we have attempted to provide a framework for students to develop an understanding of how to determine the various mechanisms that lead to altered activity of a specific protein within a cell.

Full Product Details

Author:   Gary H. Perdew ,  Jack P. Vanden Heuvel ,  Jeffrey M. Peters
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2007 ed.
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.50cm
Weight:   0.673kg
ISBN:  

9781588292650

ISBN 10:   1588292657
Pages:   333
Publication Date:   15 September 2006
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Gene Expression Control At The Mrna Level.- Overview.- Messenger RNA Accumulation.- Transcript Profiling.- Transcriptional Regulation of Gene Expression.- Posttranscriptional Processing of Messenger RNA.- Regulation Of Protein Levels And Transcription Factor Function.- Overview.- Protein Synthesis and Turnover.- Proteomics.- Determination of Protein-Protein Interactions and the Motifs That Mediate Them.- Posttranslational Modifications.- Dissection of Signaling Pathways.- Use Of Transgenic And Knockout Mice To Study Gene Regulation.- Overview.- Production of Transgenic Animals.- Knockout Animals.- Isolation of Cells and Cell Lines From Transgenic and Knockout Animals.

Reviews

From the reviews: <p> The book is aimed at graduate students, filling a gap between more general text books a ] and laboratory manuals (e.g. the Current Protocols series). a ] has many clear illustrations and these are also available in an accompanying CD. Helpful notes and key references are given in the margins throughout the text. a ] overall a ~Regulation of Gene Expression: Molecular Mechanismsa (TM) would certainly be of use to life sciences undergraduates, it would also be a useful reference work for a Molecular Toxicology laboratory. (James Sidaway, British Toxicology Society Newsletter, Summer, 2007)

From the reviews: The book is aimed at graduate students, filling a gap between more general text books ... and laboratory manuals (e.g. the Current Protocols series). ... Helpful notes and key references are given in the margins throughout the text. ... overall 'Regulation of Gene Expression: Molecular Mechanisms' would certainly be of use to life sciences undergraduates, it would also be a useful reference work for a Molecular Toxicology laboratory. (James Sidaway, British Toxicology Society Newsletter, Summer, 2007)

From the reviews: The book is aimed at graduate students, filling a gap between more general text books ... and laboratory manuals (e.g. the Current Protocols series). ... Helpful notes and key references are given in the margins throughout the text. ... overall 'Regulation of Gene Expression: Molecular Mechanisms, would certainly be of use to life sciences undergraduates, it would also be a useful reference work for a Molecular Toxicology laboratory. (James Sidaway, British Toxicology Society Newsletter, Summer, 2007)

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