Free Delivery Over $100
|
|
|||
|
||||
OverviewRegucalcin is a protein which is highly differentiated due to increased conservation of the regucalcin genes throughout evolution in vertebrates. Regucalcin plays a multifunctional role in cellular regulation, including an inhibitory role in protein kinases, protein phosphatases, NO synthase, nuclear DNA and RNA synthesis. Regucalcin suppresses an enhancement of cell proliferation and apoptotic cell death that are induced by various signalling factors. Regucalcin plays a pathophysiological role in many metabolic disorders in humans. This book introduces recent topics of regucalcin studies concerning the genomics, cell regulation and diseases associated with this protein. Full Product DetailsAuthor: Masayoshi Yamaguchi, Ph.D., IOM, FAOE, DDG, DGPublisher: Nova Science Publishers Inc Imprint: Nova Science Publishers Inc Dimensions: Width: 23.00cm , Height: 1.50cm , Length: 15.50cm Weight: 0.476kg ISBN: 9781621002598ISBN 10: 1621002594 Pages: 157 Publication Date: 01 January 2012 Audience: College/higher education , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Active Availability: Awaiting stock  The supplier is currently out of stock of this item. It will be ordered for you and placed on backorder. Once it does come back in stock, we will ship it out for you. Table of ContentsPreface; Structure of regucalcin gene; Transcriptional regulation of regucalcin gene expression; Hormonal regulation of regucalcin gene expression; Change in regucalcin gene expression in patho-physiological state; Role of regucalcin in intracellular calcium homeostasis; Reversible effect of regucalcin on calcium effect in enzyme regulation; Role of regucalcin in the regulation of nuclear signaling; Role of regucalcin in protein synthesis & degradation; Suppressive role of regucalcin in apoptosisReviewsAuthor InformationMasayoshi Yamaguchi, Ph.D., IOM, FAOE, DDG, DG, is Adjunct Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA (2013 - ). Dr. Yamaguchi is engaged in the fields of endocrinology and cell signaling since 1971, and these researches are developed in the aspect of biochemistry, molecular biology, endocrinology, metabolism, nutrition, pharmacology, and toxicology. Dr Yamaguchi has an interesting for cell signaling mechanism, bone biology, nutritional factor and osteoporosis prevention, diabetes and diabetic osteoporosis, cancer biology, and cancer cell bone metastasis. Dr. Yamaguchi discovered two novel proteins and genes; cell signaling suppressor protein (named regucalcin; 1978) and transcriptional factor RGPR-p117 (regucalcin gene promoter region-related protein; 2001). Dr Yamaguchi generated regucalcin transgenic rats, which were registered as international patents including USA, EU and Japan, and this animal was found to induce osteoporosis and hyperlipidemia. Moreover, Dr. Yamaguchi proposed the potential role of regucalcin as a key suppressor protein in carcinogenesis. Thus far, Dr Yamaguchi published over 550 English articles to professional journals with peer-review, and registered over 20 national and international patents. Tab Content 6Author Website:Countries AvailableAll regions |
||||
