Overview

Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results.

Full Product Details

Author:   Giuseppe Orlando (Section of Transplantation, Wake Forest University Baptist Medical Center Medical Center Boulevard Winston-Salem, NC, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Dimensions:   Width: 21.60cm , Height: 5.30cm , Length: 27.60cm
Weight:   3.120kg
ISBN:  

9780123985231

ISBN 10:   0123985234
Pages:   1050
Publication Date:   12 December 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Meet the Editors Preface 1. Introduction: Regenerative medicine and solid organ transplantation from a historical perspective 2. Solid organ transplantation: has the promise been kept and the needs met? Principles of Regenerative Medicine and Cell, Tissue, and Organ Bioengineering 3. Strategies for the specification of tissue engineering biomaterials 4. Principles of Stem Cell Biology 5. Principles of cell sheet technology 6. Principles of bioprinting technology 7. Synthetic biomaterial for regenerative medicine applications 8. Natural biomaterials for regenerative medicine applications 9. Bioartificial biomaterials for regenerative medicine applications 10. Bioactivated materials for cell and tissue guidance 11. Biocompatibility and immune response to biomaterials 12. Harnessing regenerative and immunomodulatory properties of stem cells 13. Bioreactors for tissue engineering purposes Kidney 14. Current status of renal transplantation 15. Living related renal transplantation: progress, pitfalls and promise 16. Machine perfusion of kidneys donated after cardiac death: the Carrel and Lindbergh legacy 17. Renal regeneration: the bioengineering approach 18. Renal regeneration: the stem cell biology approach 19. Renal regeneration: the developmental approach Liver 20. Current status of liver transplantation 21. Living related liver transplantation: progress, pitfalls and promise 22. Donation after cardiac death liver transplantation 23. Artificial liver support 24. Liver regeneration: the bioengineering approach 25. Liver regeneration: the developmental biology approach 26. Liver regeneration: the stem cell approach 27. Liver bioengineering using human cells Heart 28. Current status of heart transplantation 29. Artificial heart support 30. Heart regeneration: the bioengineering approach 31. Heart regeneration: the developmental and stem cell biology approach Small Bowel 32. Current status of intestinal transplantation 33. Living related small bowel transplantation: progress, pitfalls and promise 34. Intestinal regeneration: the bioengineering approach 35. Intestinal regeneration: the developmental biology approach 36. Intestinal regeneration: stem cell approach 37. Building blocks for engineering the small intestine Endocrine pancreas and islets of Langerhans 38. Current status of pancreas transplantation 39. Living related pancreas transplantation: progress, pitfalls and promise 40. Current status of islet transplantation 41. Pancreatic islets regeneration: the bioengineering approach 42. Pancreatic islet regeneration: the developmental and stem cell biology approach 43. Microencapsulation technology 44. Autologous islets transplantation Lung 45. Current status of lung transplantation 46. Living related lung transplantation: progress, pitfalls and promise 47. Artificial Lung Support 48. Lung regeneration: the bioengineering approach 49. Lung regeneration: the developmental biology approach 50. Lung regeneration: stem cell approach Composite tissues allotransplantation Immunosuppression-free transplantation in the regenerative medicine era Epilogue: Organ Bioengineering and Regeneration as the new Holy Grail of Organ Transplantation

Reviews

This book succeeds in providing a detailed and comprehensible description of current and future therapies for solid organ replacement. It is unique in that it encompasses all solid organs and compiles a great deal of research. It will serve as a valuable reference for all those involved in the evolution of transplantation. Rating: 4 Stars--Organ Transplantation review on Doody.com, January 24, 2014

With beautiful illustrations throughout that greatly enhance the overall reading experience of this book, this book is a must-have for anyone interested in tissue engineering and organ transplantation. This is one of the best textbooks I have come across that combines surgery with science, and it is a must for all surgeon-scientists involved in tissue engineering and organ transplantation. --BCS Online, April 3, 2014 This book succeeds in providing a detailed and comprehensible description of current and future therapies for solid organ replacement. It is unique in that it encompasses all solid organs and compiles a great deal of research. It will serve as a valuable reference for all those involved in the evolution of transplantation. Rating: 4 Stars--Organ Transplantation review on Doody.com, January 24, 2014

Author Information

Giuseppe Orlando, MD, PhD, Marie Curie Fellow, is an Associate Professor and a kidney and pancreas transplant surgeon scientist at the Wake Forest University School of Medicine, in Winston Salem, USA. His research aims at developing platforms for the bioengineering and regeneration of transplantable organs, and at developing therapies to enhance the innate ability of the human body to repair itself after damage. His literature output aims at bridging organ transplantation to regenerative medicine.

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