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OverviewRazoxane and dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of pathological blood vessels. Razoxane potentiates radiotherapy especially in the treatment of soft tissue sarcomas and gastrointestinal neoplasms. They protect normal tissues against toxic chemicals, e.g. the myocardium against anthracyclines or subcutaneous tissue against injuries caused by incidental extravasations of anthracyclines. Dexrazoxane is the only drug approved by the FDA/EMEA for the specific purpose of preventing cardiac damage when giving the widely used and effective antitumor anthracyclines. The reduction of cardiotoxicity is achieved without response reduction or reducing of time to progression of tumors. While the full analysis of their actions at the molecular level is not yet completely understood, it seems most likely that it is via an inhibition on the topoisomerase II a. Moreover, the drugs have the ability to chelate several metals including iron, copper or zinc. The protection of normal tissues is nowhere more important than that of brain, and there are indications that the proteins thought to be responsible for the ravages of Alzheimer´s disease could be stabilized by one or both these drugs. Full Product DetailsAuthor: Walter Rhomberg , Kurt HellmannPublisher: Springer Imprint: Springer Edition: 2011 ed. Dimensions: Width: 15.50cm , Height: 2.00cm , Length: 23.50cm Weight: 1.200kg ISBN: 9789048191673ISBN 10: 904819167 Pages: 243 Publication Date: 06 October 2010 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In Print This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsPREFACE; 1. INTRODUCTION; 2. RAZOXANE; 3. DEXRAZOXANE; 4. SUMMARY and OUTLOOKReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |