Overview

Rapid progress in molecular biology, genetic engineering, and basic research in immunology has opened up new possibilities for application to diagnostic procedures and to clinical research. In a short period a new era of diagnosis dawned, covering nearly all fields of microbiology, immunology, and food technology. In consequence of this rapid development, scientists of many disciplines are involved studying infections of humans, animals, and plants or working in technical microbiology. The application of the newest findings of basic research to diagnostic work and to clinical research covers nearly all fields of microbiology and immunology. Moreover, it underlines the close relationship between diagnosis, therapy, and epidemiology. An outstanding example of these connections is given by the recent development of hepatitis B vaccine. The discovery and identification of a non­ cultivable agent by physicochemical and immunological methods were the heralds of a new era in the prevention of infectious diseases. This book provides an up-to-date, comprehensive review of developments and future aspects in various fields. I am convinced that the authors have succeeded in furnishing a large variety of new ideas and possibilities. K.-O. HABERMEHL Contents Time Realities in the Evaluation of Vaccines for Safety and Efficacy The Evaluation of Vaccines M. R. HILLEMAN . . . . .

Full Product Details

Author:   K.-O. Habermehl
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1985
Dimensions:   Width: 17.00cm , Height: 3.80cm , Length: 24.40cm
Weight:   1.273kg
ISBN:  

9783642699450

ISBN 10:   3642699456
Pages:   730
Publication Date:   08 December 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Time Realities in the Evaluation of Vaccines for Safety and Efficacy.- The Evaluation of Vaccines.- Evaluation of Hepatitis B Vaccine.- Concepts in the Development of Vaccines Against Genital Herpes Simplex Virus Infections.- Development of a Live Attenuated Vaccine Against Varicella.- Hybridization Technology in Diagnostics.- The Use of DNA Hybridization for the Identification of Pathogenic Bacteria.- Microbial Diagnosis by Nucleic Acid Sandwich Hybridization.- Diagnosis of Papillomavirus Infection by Nucleic Acid Hybridization.- Detection of Epstein-Barr Virus DNA by Nucleic Acid Hybridization.- Diagnosis of Viroid-Caused Plant Diseases by Nucleic Acid Hybridization.- DNA Technology Applied to the Detection and Epidemiology of Enteric Pathogens.- New Developments in Nucleic Acid Hybridization.- Application of Monoclonal Antibodies. Hybridoma Technology.- Variability of Antigen Epitopes of Monotypic Viruses.- Immunoblotting with Monoclonal Antibodies: A Highly Specific System for Detection and Identification of Bacterial Outer Membrane Proteins.- Immunoblotting and Dot Immunobinding.- Fluorescence-Activated Cell Sorter and Monoclonal Antibodies: Complementary Tools in Immunodiagnosis and Immunotherapy.- A Microfilter Assay for the Detection of Antibody-Producing Cells In Vitro.- A Biotin Avidin Amplified ELISA Using Exclusively Monoclonal Antibodies for the Detection of Respiratory Syncytial Viral Antigens in Nasopharyngeal Secretions.- Identification and Serotyping of Vibrio cholerae 0:1 by Monoclonal Antibody Based Enzyme-Linked Immunosorbent Assays.- Rapid Diagnosis by IgM-Detection.- The Role of Specific Antibodies in Different Immunoglobulin Classes in Rapid Diagnosis of Virus Infections.- Problems of Rubella Diagnosis by Various IgM Techniques and the Need for Test Combinations.- The Role of Specific Antibodies of Different Immunoglobulin Classes in the Rapid Diagnosis of Systemic Mycotic Infections.- The Role of Specific Antibodies in Different Immunoglobulin Classes in the Rapid Diagnosis of Diseases Caused by Treponemes.- Physical Detection of Microorganisms.- NMR in the Study of Cells and Tissues.- Rapid Microbial Identification by Circular Intensity Differential Scattering.- An Instrument for Virus Identification by Polarized Light Scattering: A Preliminary Report.- A New Method for the Rapid Identification and Differentiation of Pathogenic Microorganisms Using Fourier Transform Infrared Spectroscopy.- The Use of Microcalorimetry and Impedance in Clinical Microbiology.- The Photometric Analysis of Microbial Growth for the Identification and Antimicrobial Susceptibility Testing of Bacterial Pathogens.- The Application of Impediometry to Rapid Antibiotic Susceptibility Testing and Early Detection of Bacterial Growth.- Chromatographic Analysis of Microbial Components.- Chromatographic Analysis for Identification of Microorganisms and Diagnosis of Infection: An Introduction.- Chromatographic Analysis of Bacterial Cellular Components.- Analysis of Bacterial Metabolites and Components by Computerized GC/MS System - From Shorter Chain Acids to Very Long-Chain Compounds up to C80.- Gas Chromatographic Analysis of Clinical Samples for Rapid Diagnosis of Infection.- Pyrolysis Gas-Liquid Chromatography for Identification of Microorganisms.- Taxonomic Calculations Based on Fatty Acid Spectra of Bacteria. Requirements for Chromatographic Analysis of Fatty Acids.- Extraction and Chromatographic Analysis of Characteristic Mycobacterial Lipids.- Isolation of Microorganisms.- Progress in Methods for More Rapid Isolation of Agents Responsible for Bacteremia.- Mechanical Plate Spreading — From Concept to Realisation.- COBAS Bact: The Centrifugal Approach to Clinical Bacteriology.- Short-Term Methods for Isolation and Enumeration of Bacteria in the Respiratory Tract.- Some New Media for Isolation and Rapid Identification of Bacteria.- Antigen Detection and Identification.- Current Trends and Practical Application in Rapid Viral Diagnosis.- Respiratory Viral Antigen Detection by Solid-Phase Immunoassays: Comparison with Other Diagnostic Tests and Application for Routine Diagnosis.- Coagglutination Procedures and Affinity Chromatography in Antigen and Antibody Detection.- Instrumental Methods for Antigen Detection.- Detection of Group A Streptococcal Antigen by Coagglutination and Latex Agglutination.- Growth-Independent Rapid Automated Enzyme Identification System.- An Automatic Micromethod for the Identification of Gram-Negative Bacilli by Carbon Substrate Assimilation Tests.- Rapid Typing of Pili of Pathogenic Escherichia coli by Dispersive Immunoelectron’ Microscopy.- Fluoroimmunoassays, Time-Resolved Fluorometry, and Bioluminescence.- Enzyme Immunoassays Using Fluorescent Substrates.- Identification of Bacteria by Flow Immunofluorescence.- The Principle of Time-Resolved Fluorometry.- Microbiologic Applications of Fluoroimmunoassay.- Detection of Viral Antigens by Time-Resolved Fluoroimmunoassay.- Monitoring Miccrobial Growth by Bioluminescent ATP Assay.- Bioluminescent Assay of Bacterial ATP as a Tool in Clinical Microbiology.- Bacteriuria Detection in an Outpatient Setting: Comparison of Several Methods Including an Improved Asssay of Bacterial ATP.- Analytical Use of Luminous Bacteria in Veterinary and Medical Microbiology.- Susceptibility Tests for Antimicrobial Agents and Assays in Fluids and Tissues.- Antimicrobial Susceptibility Testing Using Fluorogenic Enzyme Substrates.- Antimicrobial Susceptibility Tests: Automation and Mechanization.- Techniques for In Vitro Tests on New Antibiotics.- MIC Reading with the Biology Laboratory Computer.- The Alteration of Microbial Growth Curves by Antibiotics.- Clinical Needs for Determination of Antimicrobial Agents in Fluids and Tissues.- Methods for Detection of Antimicrobial-Induced Changes in the Normal Human Oropharyngeal and Colon Microflora.- Chromatographic Methods for Determination of Antimicrobial Agents in Fluids and Tissues.- Microbiological and Immunological Assays of Antimicrobials.- Computerized Pharmacokinetic Evaluation of Antibiotics in Body Fluids and Tissues: An Overview.- Data Processing in Microbiology and Serology.- Data Handling and Retrieval in Clinical Virology by Small Decentralized Computers.- Application of Small Decentralized Computers in the Management of Bacteriologic Data in the Clinical Laboratory.- MicroLab and MikroSeek — A New Approach to Computing in Medical Microbiology.- The Use of the Computer to Aid Decision Making by the Food Microbiologist.- Computer-Assisted Reading System for Microbiological Tests.- Problems in Operation and Data Transfer in a Multicomputer Environment.- Food Control and Monitoring of the Environment.- A Philosophical Approach to Rapid Methods for Industrial Food Control.- Essentials of Enumeration and Identification Methods for Microorganisms Which Interfere with the Safety of Foods with Particular Reference to Simplification Avoiding the Use of Nonconventional Instrumentation.- Membrane Filter Techniques for Food Microbiological Analysis.- Status and Future of the Direct Epifluorescent Filter Technique.- Application of the Limulus Test for Detection of Gram-Negative Microorganisms in Milk and Dairy Prooducts.- Enzyme-Linked Immunosorbent Assay of Staphylococcal Enterotoxins in Foods.- Procedures and Methods for One-Day Analysis of Microbial Loads in Foods.- The Potential of Chromatographic Techniques for the Manipulation of Viable Micro-Organisms.- Electrical Impedance Method for Determining Microbial Quality of Foods.- Are Rapid and Sensitive Microbiological Procedures Necessary for Monitoring the Environment?.- Searching for Rapid Methods in Environmental Bacteriology.- Application of Automated and Rapid Microbiologic Assays in Various Health-Care Environments.- Problems in Detecting Water-Borne Viruses by Rapid Methods.- Detection and Identification of Viruses in Water by Immunoadsorbance and Energy Transfer.

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