Overview

Continuous genetic variation and selection of virus subpopulations in the course of RNA virus replications are intimately related to viral disease mechanisms. The central topics of this volume are the origins of the quasispecies concept, and the implications of quasispecies dynamics for viral populations.

Full Product Details

Author:   Esteban Domingo
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   1st ed. Softcover of orig. ed. 2006
Volume:   299
Weight:   0.646kg
ISBN:  

9783642065828

ISBN 10:   3642065821
Pages:   410
Publication Date:   12 February 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

What Is a Quasispecies?.- Quasispecies in Time-Dependent Environments.- Viruses as Quasispecies: Biological Implications.- Virus Fitness: Concept, Quantification, and Application to HIV Population Dynamics.- Population Bottlenecks in Quasispecies Dynamics.- Evolutionary Dynamics of HIV-1 and the Control of AIDS.- Evolution of Virulence in Picornaviruses.- Molecular Mechanisms of Poliovirus Variation and Evolution.- Hepatitis C Virus Population Dynamics During Infection.- Evolutionary Influences in Arboviral Disease.- Arenavirus Diversity and Evolution: Quasispecies In Vivo.- Mutant Clouds and Occupation of Sequence Space in Plant RNA Viruses.- Parvovirus Variation for Disease: A Difference with RNA Viruses?.- Transitions in Understanding of RNA Viruses: A Historical Perspective.

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