Overview

Quantitative Gas Chromatography-Mass Spectrometry: Principles in Life Sciences and Biochemical Applications provides an in-depth exploration of the principles and practices of GC-MS. This comprehensive guide caters to researchers, academics, and graduate students engaged in analytical chemistry, offering both theoretical knowledge and practical applications. The book is structured to introduce the fundamentals before delving into advanced techniques, ensuring a thorough understanding for all readers. The book covers essential topics such as gas chromatography-tandem mass spectrometry, liquid chromatography-tandem mass spectrometry, and the use of stable isotopes and labeled analogs. It also presents practical advice on method development, validation, and quality control. Additionally, it addresses common issues and troubleshooting in GC-MS, making it a valuable resource for those in fields like Biochemistry, Pharmacology, Forensic Medicine, and Metabolomics.

Full Product Details

Author:   Dimitrios Tsikas (Professor, Institute of Toxicology, Core Unit Proteomics, Hannover Medical School, Germany)
Publisher:   Elsevier - Health Sciences Division
Imprint:   Elsevier - Health Sciences Division
Weight:   0.450kg
ISBN:  

9780443300967

ISBN 10:   0443300968
Pages:   734
Publication Date:   08 December 2025
Audience:   Professional and scholarly ,  College/higher education ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. PREFACE - Instrumental Quantitative Analytical Chemistry: GC-MS, GC-MS/MS; LC-MS, LC-MS/MS 2a. PRINCIPLES OF GAS CHROMATOGRAPHY-MASS SPECTROMETRY 2b. PRINCIPLES OF GAS CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY 2c. PRINSIPLES OF LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY 3. CHEMICAL IONIZATION, ELECTRON IONIZATION 4. STABLE ISOTOPOLOGUES AS INTERNAL STANDARDS, STANDARDIZATION 5. METABOLIC PATHWAYS - PHYSIOLOGICAL SUBSTANCES, BIOMARKERS, CREATININE 6. HEALTH and DISEASE 7. PHARMACOLOGY 8a. BIOCHEMICAL AND CLINICAL STUDIES 8b. PRE-ANALYTICAL AND ANALYTICAL ISSUES 9. EXTRACTION - SOLID, SOLVENT, AFFINITY CHROMATOGRAPHY 10. CHEMICAL DERIVATIZATION - METHYLATION; PFBBr; PFPA 11. QUANTITATIVE ANALYSIS - ACCURACY, PRECISION, LOD, LOQ 12. METHOD VALIDATION AND COMPARISON 13. QUALITY CONTROL 14. ISOTOPE EFFECTS IN CHROMATOGRAPHY 15. BIOCHEMICAL AND BIOMEDICAL APPLICATIONS 15a. NITRITE, NITRATE, CREATININE, CARBONATE, MALONDIALDEHYDE 15b. PROSTAGLANDIN, THROMBOXANE, LEUKOTRIENES, FATTY ACIDS 15c. AMINO ACIDS 15d. BIOGENIC AMINES MISCELLANEOUS SUMMARY REFERENCES - Each chapter will have its own references LIST OF ABBREVIATIONS - for all chapters together

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Author Information

Dimitros Tsikas is a Professor at the Institute of Toxicology, Core Unit Proteomics in Hannover Medical School.

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