Overview

This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish tolearn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies.

Full Product Details

Author:   Ingolf Sack ,  Tobias Schaeffter
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   Softcover reprint of the original 1st ed. 2018
Weight:   1.035kg
ISBN:  

9783030097554

ISBN 10:   3030097552
Pages:   497
Publication Date:   04 February 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

PART I: Tissue properties   1.         Sack             Multiscale biophysical interactions and parameters in medical imaging   2.         Taupitz             The Extracellular matrix as target for medical imaging   3.         Käs             Single cell physical properties and collective behavior in tumors.   4.         Hirsch             Biot's theory of biphasic poroelastic media and its application to incompressible tissue   5.       &nb sp; Wall/Caiazzo             Fluid dynamics in living systems     PART II: Imaging technology & data analysis   6.         Kutyniok             Mathematical Methods in Medical Image Processing   7.         Dewey, Kachelrieß             Computed Tomography: Acquisition and Reconstruction   8.         Tzschätzsch             Ultrasound elastography methods   9.         Buchert             PET measured water perfusion   10.       Abram             Innovative radiotracers for PET   11.       Schröder             CEST-MRI   12.       Schäffter/Kolbitsch             Acceleration strategies for data sampling in MRI   13.       Laufer             Photoacoustic tomography     PART III: Medical applications   14.       Fischer, Thomas             Tumor characterization by ultrasound perfusion meas urements and elastography   15.       Schmitter             4D flow quantification in cardiovascular MRI   16.       Schäffter             Cardiac perfusion MRI   17.       Guo             Noninvasive assessment of pressure-related imaging parameters in portal hypertension   18.       Dewey, Kachelrieß             Biophysical Parameters measured by dynamic computed tomography in the clinic   19.       Brenner             Quan tification of functional heterogeneities in tumors by PET imaging   20.       Niendorf        Magnetic Resonance Myocardial Effective Transverse Relaxation Time at 7.0 Tesla      for a Better Understanding of Myocardial (Patho)physiology.

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Author Information

Ingolf Sack is a Heisenberg professor of the German Research Foundation for Experimental Radiology and Elastography at Charité-Universitätsmedizin Berlin, Germany. He received a PhD in Chemistry from Freie Universität Berlin for the development of methods in NMR spectroscopy. He then worked at the Weizmann Institute in Rehovot, Israel and at the Sunnybrook Hospital, Toronto. Since 2003 he has led an interdisciplinary team of physicists, engineers, chemists, and physicians who have pioneered pivotal developments in time-harmonic elastography of both MRI and ultrasound for many medical applications. Tobias Schaeffter is the head of divison of Medical Physics and metrological IT at the Physikalisch-Technische Bundesanstalt (PTB) in Berlin, Germany. He is also Professor in Imaging Sciences at the department of biomedical engineering at King’s College London, UK. Tobias Schaeffter studied electrical engineering at TU-Berlin and did his PhD in magnetic resonance spectroscopic imaging (MRSI) under supervision of Prof. Leibfritz at University Bremen in 1996. From 1996-2006, he worked as a Principal Scientist at the Philips Research Laboratories in Hamburg, Germany, where he managed MR-research projects , their clinical evaluation and product integration. In April 2006, he took up the Philip Harris Professorship of Imaging Sciences at King’s College London. In 2012 he became department head of biomedical engineering and was director of the doctorial training centre in medical imaging. Since 2015 he moved to  PTB as a head of divison. A major aim of his research is the investigation of fast and quantitative MR-techniques for cardiovascular applications. 

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