Awards

• Commended for PROSE (Biological Sciences) 2010

Overview

Psychiatric Pharmacogenomics is a book written to help clinicians to use pharmacogenomic testing to improve the pharmacotherapy that they provide for their patients. It is designed to teach clinicians how to order pharmacogenomic tests and interpret the results. Clinical examples are used to underscore the specific indications for pharmacogenomic testing and to clarify the clinical usefulness of identifying atypical genotypes that result in problematic responses to medication.The first section of the book begins with a basic review of molecular genetics. Additionally, the book also includes an extensive glossary of technical terms associated with molecular genetics and pharmacogenomics. The clinical utility of pharmacogenomic testing is demonstrated throughout the book by describing the implications of genetic variations for the care of individual patients. The second section of the book is organized into fourteen chapters that each focus on the clinical implications of testing for specific genes for which variants have been associated with either therapeutic response or side effects of psychotropic medications. Each of these chapters is structured in the same manner and involves a description of the gene and its significant variants. Each chapter also includes one or more clinical vignettes. The third section of the book discusses the clinical usefulness of pharmacogenomic testing, ethical issues associated with pharmacogenomic testing, and provides predictions for the future development of more sophisticated pharmacogenomic testing.

Full Product Details

Author:   David Mrazek (Chair of the Department of Psychiatry and Psycholo, Chair of the Department of Psychiatry and Psycholo, Mayo Clinic College of Medicine, Rochester, MN)
Publisher:   Oxford University Press Inc
Imprint:   Oxford University Press Inc
Dimensions:   Width: 23.60cm , Height: 2.80cm , Length: 16.00cm
Weight:   0.587kg
ISBN:  

9780195367294

ISBN 10:   0195367294
Pages:   280
Publication Date:   10 June 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   To order  
Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us.

Table of Contents

Table of Contents I. Basic Foundations Introduction Chapter 1 - The Language of Molecular Genetics Chapter 2 - The Fourteen Genes Chapter 3 - The Problem and the Solution II. The Drug Metabolizing Enzyme Genes Chapter 4 - The Cytochrome P450 2D6 Gene Chapter 5 - The Cytochrome P450 2C19 Gene Chapter 6 - The Cytochrome P450 2C9 Gene Chapter 7 - The Cytochrome P450 1A2 Gene III. A Gene Associated with the Metabolism of Neurotransmitters Chapter 8 - The Catechol-O-Methyltransferase Gene IV. The Neurotransmitter Transporter Genes Chapter 9 - The SLC6A2 Norepinephrine Transporter Gene Chapter 10 - The SLC6A3 Dopamine Transporter Gene Chapter 11 - The SLC6A4 Serotonin Transporter Gene V. The Serotonin Receptor Genes Chapter 12 - The Serotonin 1A Receptor Gene Chapter 13 - The Serotonin 2A Receptor Gene Chapter 14 - The Serotonin 2C Receptor Gene VI. The Dopamine Receptor Genes Chapter 15 - The Dopamine D2 Receptor Gene Chapter 16 - The Dopamine D3 Receptor Gene Chapter 17 - The Dopamine D4 Receptor Gene VII. Clinical Considerations Chapter 18 - The Clinical Utility of Psychiatric Pharmacogenomic Testing Chapter 19 - Ethical Issues to Consider When Using Pharmacogenomic Testing in Psychiatric Practice Chapter 20 - Future Development of Psychiatric Pharmacogenomic Testing Glossary of Genetic and Pharmacogenomic Terms Generic and Brand Names of Pharmacogenomically Relevant Drugs Index

Reviews

This is a superb book on a very useful topic in clinical psychiatry. All psychiatrists need to be versed in the wisdom this book provides. I highly recommend it. * Doody's Notes *

<br> Psychiatric Pharmacogenomics, authored by David A. Mrazek, M.D., F.R.C. Psych., is the most authoritative book in the field of psychiatric genetics produced in the XXI Century. This text is not only an ideal tool for the busy clinician, but also offers the knowledge required by educators and investigators in the field of psychiatry pharmacogenomics at large. --Pedro Ruiz, MD, President, American Psychiatric Association (2006-2007); President Elect, World Psychiatric Association (2008-2011); and Professor of Psychiatry and Vice Chair for Education, Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston, Texas<br> In his book on psychiatric pharmacogenomics, Dr. Mrazek distils his scientific wisdom with clinical insights, to produce a unique guide to the theory and practice of this nascent specialty. He takes us on a journey of discovery, from the initial perplexing observations that different patients respond differently to the same medicati

This is a superb book on a very useful topic in clinical psychiatry. All psychiatrists need to be versed in the wisdom this book provides. I highly recommend it. Doody's Notes

Author Information

David A. Mrazek, M.D., F.R.C.Psych. Chair of Psychiatry and Psychology, Mayo Clinic Professor of Psychiatry and Pediatrics Mayo Clinic College of Medicine Rochester, Minnesota

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