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9780470120538

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The burgeoning are of chemical biology encompasses many subfields. While it undergoes constant changes in what it covers necessitated by the rapid changes in both chemistry and biology, one central theme has remained constant--the use of small molecules as probes of myriad biological processes. The majority of bioactive small molecules of interest to chemical biologists manifest their unique and selective biological effects through binding to and interfering with the function of proteins. As such, experimental tools and techniques for detecting and deconvoluting the interactions between small molecules and proteins are of great interest to contemporary chemical biologists. The book entitled Protein Targetting with Small Molecules edited by Dr. Hiroyuki Osada thus fulfills an important void in the field. In this book, different experimental approaches and techniques were reviewed by the frontline practitioners in the field. Both theoretical and practical aspects of each general technique are thoughtfully covered, which were further illustrated by specific examples. It can serve multiple purposes, as a text book for graduate level chemical biology education and a reference book for those looking for new tools to study small-molecule protein and even small molecule-pathway interactions. ?Dr. Jun Liu, Johns Hopkins University School of Medicine The book edited by Hiroyuki Osada, one of the foremost chemical biologists of the time, aims at covering this enormously wide field by twelve complementary reviews written by experts in their individual areas of research.... Taken together the book provides a widespread overview of numerous techniques, approaches and methods typically applied in small molecule ligand design, synthesis, screening, target identification and validation as well as applications in selected fields.... Thus, while reading the chapters, the reader is exposed to the variety of chemical, biophysical, biochemical and biological techniques typically applied in small molecule based chemical biology research.... As such, I strongly recommend the book to researchers with advanced training in chemistry, biophysics, biochemistry and biology with a desire to branch out their research into neighboring disciplines and ready to become chemical biologists. ?Prof. Dr. Herbert Waldmann, Max Planck Institute of Molecular Physiology

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Hiroyuki Osada is the Director and Chief Scientist in the Chemical Biology Department of RIKEN Advanced Science Institute and he is heading the RIKEN Natural Products Depository, RIKEN NPDepo. He is a former research fellow at the National Cancer Institute of the NIH. Dr. Osada is on the advisory boards of ACS Chemical Biology and Chemistry: An Asian Journal. In addition, he is an editorial member of four other journals, including Journal of Antibiotics and Journal of Microbiology and Biotechnology.

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