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Overview"This text covers aspects of protein structural biology which have led to recognition of fundamental relationships between protein structure and function. The first two chapters, for example, are concerned with identification and design of specific ligand binding site. Chapter 1, ""Protein Crystallography in Medicine"" describes medically-relevant proteins for which crystal structures have provided targets for drug design. Chapter 2 introduces strategies used in design of proteins with specified binding capabilities, and chapter 3 explores the most useful depictions of protein structure. Other topics covered in the rest of the book include ""threading""; the mathematical basis for probabilistic methods and the application of molecular dynamics simulations to problems of molecular recognition." Full Product DetailsAuthor: C. Woodward (Department of Biochemistry, University of Minnesota, St. Paul, MN, USA) , N.M. Allewell (Department of Biochemistry, University of Minnesota, St. Paul, MN, USA) , E. Edward BittarPublisher: Elsevier Science & Technology Imprint: JAI Press Inc. Volume: 22 Dimensions: Width: 15.60cm , Height: 2.00cm , Length: 23.40cm Weight: 0.660kg ISBN: 9780762302833ISBN 10: 0762302836 Pages: 626 Publication Date: 16 January 1998 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Out of Print Availability: In Print  Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock. Table of ContentsProtein Crystallography in Medicine (M.J. Rynkiewicz and B.A. Seaton). Engineering Metal Binding Sites in Proteins (L. Regan). Using Molecular Graphics to Analyze Protein Structures (H. Oberoi and N.M. Allewell). Electrostatics and Hydrogen Bonding (B. Garcia-Moreno E.). Protein Structure Determination by Nuclear Magnetic Resonance Spectroscopy (I.M. Russu). Membrane Protein Structure (M.P. McCarthy). Structural Features of Membrane Proteins (T. Haltia). Experimental Dissection of Protein-Protein Interactions in Solution (M.L. Doyle and P. Hensley).ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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