Overview

This book provides an up-to-date and comprehensive overview of protein phosphatase research, a rapidly evolving field with increasing importance in our understanding of the molecular basis of cell biology and of pathological processes. The book covers dephosphorylation processes involving serine/threonine, as well as tyrosine and histidine residues, and aims to be a useful resource for both the advanced reader as well as the newcomer to the field. It is also valuable for those working in the pharmaceutical and Biotech industries.

Full Product Details

Author:   Joaquín Arino ,  Denis Alexander
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of hardcover 1st ed. 2004
Volume:   5
Weight:   0.605kg
ISBN:  

9783642058172

ISBN 10:   3642058175
Pages:   378
Publication Date:   10 April 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Overview of Protein Serine/Threonine Phosphatases.- Protein Phosphatase 1.- Protein Phosphatase 2A: A Multifunctional Regulator of Cell Signaling.- Calcineurin: Roles of the Ca2+/Calmodulin-dependent Protein Phosphatase in Diverse Eukaryotes.- Roles of Mammalian Protein Phosphatase 2C Family Members in the Regulation of Cellular Functions.- PP5: the TPR Phosphatase.- Protein Histidine Phosphatases in Signal Transduction and Metabolism.- Anchoring of Protein Kinase and Phosphatase Signaling Units.- Functional Proteomics in Phosphatase Research.- Structure and Function of the T-cell Protein Tyrosine Phosphatase.- Protein Tyrosine Phosphatase-based Therapeutics: Lessons From PTP1B.- The CD45 Phosphotyrosine Phosphatase.- Receptor Protein Tyrosine Phosphatases.- The Shp-2 Tyrosine Phosphatase.- SHP-1 Twelve Years on: Structure, Ligands, Substrates and Biological Roles.- The Dual-specific Protein Tyrosine Phosphatase Family.- Tyrosine Phosphatases in Cancer: Targets for Therapeutic Intervention.

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