Overview

Protein Misfolding Diseases, delves into the intricate molecular mechanisms behind a class of devastating disorders caused by abnormal protein folding. This comprehensive book explores interesting and updated topics, including Protein misfolding in hemophilia, Characterizing Protein Misfolding: Inside and Out, Heat Shock proteins (HSPs) as chaperones for Oncogenesis, Protein Misfolding and Cancer: Molecular Insights and Future Perspectives, Proteostasis and Pathogenesis: Unraveling the Complexity of Protein Misfolding Disorders, Small molecule inhibitors targeting α-synuclein aggregation: Progress and future outlook, and much more. Additional sections cover Chaperone Machinery in Neurodegeneration: A Spotlight on Protein Misfolding Diseases and Calpain- mediated proteolytic cleavage.

Full Product Details

Author:   Rossen Donev (Head of Research, MicroPharm Limited, UK) ,  Ajaz A. Bhat
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.450kg
ISBN:  

9780443294143

ISBN 10:   0443294143
Pages:   488
Publication Date:   01 December 2025
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
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Table of Contents

1. Protein misfolding in hemophilia Bilgimol Chumappumkal Joseph, Nicca Falah, Juan Andres De Pablo-Moreno, Dana H Simmons and Annette von Drygalski 2. TBD Sarita Montaño 3. TBD Sreejith Madhavankutty 4. Characterizing Protein Misfolding: Inside and Out Amritangshu Chakravarty 5. TBD Krishnamurthy Nakuluri and Vani Gowru 6. TBD Shahab Uddin, Abdul Ansari, Aamir Ahmad, Lubna Therachiyil, Gazala Anamangadan, Manel Sadok and Hesham M Korashy 7. Longitudinal plasma proteome of vaccinated individuals reveals altered factors associated with blood coagulation and immune responses Aamir Ahmad 8. TBD Muzafar Ahmad Macha 9. TBD Manzoor A. Mir Sr. 10. Heat Shock proteins (HSPs) as chaperones for Oncogenesis Mayank Singh 11. TBD Ajaz Ahmad Bhat 12. Protein Misfolding and Cancer: Molecular Insights and Future Perspectives Sireesha V. Garimella and Geethika Ishani Makka 13. Proteostasis and Pathogenesis: Unraveling the Complexity of Protein Misfolding Disorders Biplab Singha, Tripti Nair, Ditsa Sarkar, Sumit Murmu and Rahul Rawat 14. TBD Surbhi Sharma 15. TBD Rakesh Kumar I 16. Small molecule inhibitors targeting α-synuclein aggregation: Progress and future outlook Tanveer Ali Dar Sr., Ishfaq Bashir Hajam, Ishfaq Ahmad Ahanger and Umar Rasool 17. Chaperone Machinery in Neurodegeneration: A Spotlight on Protein Misfolding Diseases Arpit Mehrotra, Abhilasha Sood, Deepak Kumar Sharma, Madhumita Dey and Arpit Tyagi 18. Title yet to decide Shivani Mittal 19. Calpain- mediated proteolytic cleavage Subashchandrabose Chinnathambi, Nagaraj Rangappa and Tushar Dubey

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Author Information

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

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