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Author:   Lukas K. Tamm
Publisher:   Wiley-VCH Verlag GmbH
Imprint:   Wiley-VCH Verlag GmbH
Dimensions:   Width: 18.60cm , Height: 2.80cm , Length: 24.60cm
Weight:   1.022kg
ISBN:  

9783527311514

ISBN 10:   3527311513
Pages:   470
Publication Date:   26 August 2005
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Awaiting stock  

Table of Contents

Preface. List of Contributors. PART I: HOW LIPIDS SHAPE PROTEINS. 1. Lipid Bilayers, Translocons, and the Shaping of Polypeptide Structure (S. White, et al.). 2. Folding and Stability of Monomeric beta-Barrel Membrane Proteins (J. Kleinschmidt). 3. A Paradigm of Membrane Protein Folding: Principles, Kinetics and Stability of Bacteriorhodopsin Folding (P. Booth). 4. Post-Integration Misassembly of Membrane Proteins and Disease (C. Sanders). PART II: HOW PROTEINS SHAPE LIPIDS. 5. A Census of Ordered Lipids and Detergents in X-ray Crystal Structures of Integral Membrane Proteins (M. Wiener). 6. Lipid and Detergent Interactions with Membrane Proteins Derived from Solution Nuclear Magnetic Resonance (A. Arora). PART III: MEMBRANE PENETRATION BY TOXINS. 7. Lipid Interactions of a-Helical Protein Toxins (G. Anderluh & J. Lakey). 8. Membrane Recognition and Pore Formation by Bacterial Pore-forming Toxins (A. Heuck & A. Johnson). 9. Mechanism of Membrane Permeation and Pore Formation by Antimicrobial Peptides (Y. Shai). PART IV: MECHANISMS OF MEMBRANE FUSION. 10. Cell Fusion in Development and Disease (B. Podbilewicz & L. Chermomodik). 11. Molecular Mechanisms of Intracellular Membrane Fusion (O. Vites & R. Jahn). 12. Interplay of Proteins and Lipids in Virus Entry by Membrane Fusion (A. Lai, et al.). PART V: CHOLESTEROL, LIPID RAFTS, AND PROTEIN SORTING. 13. Protein-Lipid Interactions in the Formation of Raft Microdomains in Biololgical Membranes (A. Kusumi, et al.). 14. Protein and Lipid Partitioning in Locally Heterogeneous Model Membranes (P. Schwille, et al.). PART VI: TARGETING OF EXTRINSIC MEMBRANE PROTEIN MODULES TO MEMBRANES AND SIGNAL TRANSDUCTION. 15. In vitro and Cellular Membrane-binding Mechanisms of Membrane-targeting Domains (W. Cho & R. Stahelin). 16. Structure and Interactions of C2 Domains at Membrane Surfaces (D. Cafiso). 17. Structural Mechanisms of Allosteric Regulation by Membrane-binding Domains (B. Canagarajah, et al.). Subject Index.

Reviews

"""...the demand for this volume by members of my laboratory was so great that I had to pry it out of several pairs of hands in order to write this review."" (The Quarterly Review of Biology, September 2006)"

...the demand for this volume by members of my laboratory was so great that I had to pry it out of several pairs of hands in order to write this review. (The Quarterly Review of Biology, September 2006)

Author Information

Lukas Tamm studied Molecular Biology and Biophysics at the University of Basel (Switzerland) and at Cornell University. After obtaining his PhD in Biophysics from the University of Basel in 1982, he moved to Stanford University for postdoctoral work with H. M. McConnell. Returning to Basel, he was appointed as a junior faculty member before joining thefaculty of the University of Virgina in 1990. He currently holds a chair in Molecular Physiology and Biological Physics and served as director of heinterdisciplinary program in biophysics at the University of Virginia from 1999-2003.

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