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OverviewProtein Folding Protocols presents protocols for studying and characterizing steps and conformational ensembles populating pathways in protein folding from the unfolded to the folded state. It further presents a sample of approaches toward the prediction of protein structure starting from the amino acid sequence, in the absence of overall homologous sequences. Protein folding is a crucial step in the transfer of genetic information from the DNA to the protein. The Genome Project has led to a huge number of available DNA sequences and, therefore, protein sequences. The Structural Genomics initiative largely aims to obtain “new” folds not currently present in the Protein Data Bank. Yet, the number of available structures inevitably lags behind the number of sequences. At the same time, an equally important problem is to find out the types and scope of dissimilar (nonhomologous) protein sequences that adopt a similar fold. Assembling data and comprehension of the sequence space of protein folds should be very useful in computational protein structure prediction. This would enhance the scope of homology modeling, which currently is the method of choice. Thus, experimental and theoretical studies on the relationship between sequence and structure are critical. Figuring out the relationship between sequence and structure would further assist in the prediction of fibril structures observed in protein misfolding diseases, and in figuring out the conformational changes and dynamics resulting from mutations. Protein folding is one of the most important and challenging problems in current molecular and chemical biology. Full Product DetailsAuthor: Yawen BaiPublisher: Humana Press Inc. Imprint: Humana Press Inc. Edition: 2006 ed. Volume: 350 Dimensions: Width: 15.50cm , Height: 2.00cm , Length: 23.50cm Weight: 0.659kg ISBN: 9781588296221ISBN 10: 1588296229 Pages: 328 Publication Date: 24 July 2006 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsInfrared Temperature-Jump Study of the Folding Dynamics of ?-Helices and ?-Hairpins.- The Use of High-Pressure Nuclear Magnetic Resonance to Study Protein Folding.- Characterization of Denatured Proteins Using Residual Dipolar Couplings.- Characterizing Residual Structure in Disordered Protein States Using Nuclear Magnetic Resonance.- Population and Structure Determination of Hidden Folding Intermediates by Native-State Hydrogen Exchange-Directed Protein Engineering and Nuclear Magnetic Resonance.- Characterizing Protein Folding Transition States Using ?-Analysis.- Advances in the Analysis of Conformational Transitions in Peptides Using Differential Scanning Calorimetry.- Application of Single Molecule Förster Resonance Energy Transfer to Protein Folding.- Single Molecule Studies of Protein Folding Using Atomic Force Microscopy.- Using Triplet-Triplet Energy Transfer to Measure Conformational Dynamics in Polypeptide Chains.- A Hierarchical Protein Folding Scheme Based on the Building Block Folding Model.- Replica Exchange Molecular Dynamics Method for Protein Folding Simulation.- Estimation of Folding Probabilities and ? Values From Molecular Dynamics Simulations of Reversible Peptide Folding.- Packing Regularities in Biological Structures Relate to Their Dynamics.- Intermediates and Transition States in Protein Folding.- Thinking the Impossible.Reviews"""...great value to graduate students and researchers who would like to learn about modern techniques to probe protein folding events."" -Journal of American Chemical Society" .,. great value to graduate students and researchers who would like to learn about modern techniques to probe protein folding events. -Journal of American Chemical Society ...great value to graduate students and researchers who would like to learn about modern techniques to probe protein folding events. -Journal of American Chemical Society Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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