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Author:   Cláudio M. Gomes (Universidade Nova de Lisboa, Portugal) ,  Pernilla Wittung-Stafshede (Umea University, Sweden)
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Dimensions:   Width: 15.60cm , Height: 1.90cm , Length: 23.40cm
Weight:   0.589kg
ISBN:  

9781439809648

ISBN 10:   143980964
Pages:   308
Publication Date:   05 October 2010
Audience:   College/higher education ,  General/trade ,  Tertiary & Higher Education ,  General
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

FOLDING AND STABILITY OF METALLOPROTEINS : Metal Ions, Protein Folding, and Conformational States: An Introduction. The Folding Mechanism of c-Type Cytochromes. The Mechanism of Cytochrome c Folding: Early Events and Kinetic Intermediates. Stability and Folding of Copper-Binding Proteins. Iron-Sulfur Clusters, Protein Folds, and Ferredoxin Stability. Folding and Stability of Myoglobins and Hemoglobins. MECHANISMS OF METAL TRANSPORTERS, AND ASSEMBLY: Frataxin: An Unusual Metal-Binding Protein in Search of a Function. Mechanism of Human Copper Transporter Wilson’s Disease Protein. METAL IONS, PROTEIN CONFORMATION, AND DISEASE: α-Synuclein and Metals.Zinc and Misfolding. The Octarepeat Domain of the Prion Protein and Its Role in Metal Ion Coordination and Disease. METALLOPROTEIN DESIGN, SIMULATION, AND MODELS: Metallopeptides as Tools to Understand Metalloprotein Folding and Stability. The Folding Landscapes of Metalloproteins.

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Author Information

Claudio M. Gomes is group leader at the Instituto Tecnologia Quimica e Biologica, a research institute affiliated with the Universidade Nova de Lisboa, Oeiras, Portugal. Born in 1970, Claudio earned his PhD from the Instituto Tecnologia Quimica e Biologica in 1999, as a Gulbenkian PhD program in biology and medicine graduate. From 2000 onward, he gradually switched his research interests from bioenergetics and metalloprotein structure-function toward protein folding and structural biophysics of misfolding diseases. Until setting up his independent laboratory in 2003, he was assistant professor at the Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, where he started teaching in 2000. Claudio has published more than 70 peer-reviewed papers. Pernilla Wittung-Stafshede has been a professor in biological chemistry in the Chemistry Department at Umea University, Umea, Sweden since 2008. Born in 1968, she earned a PhD in physical chemistry from Chalmers University, Gothenburg, Sweden, in 1996. During 1997--1998, she did a postdoctoral period at Caltech, Pasadena, California. In 1999 she began her independent research career, with a focus on the role of metals in protein folding, as a chemistry professor at Tulane University, New Orleans, Louisiana. After 5 years at Tulane, she moved to Rice University, Houston, Texas in 2004 and became a professor in biochemistry. Pernilla has graduated 10 PhD students to date, has obtained several awards, and has published over 150 peer-reviewed papers.

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