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Overview"Site-specific mutagenesis of DNA, developed some thirty years ago, has proven to be one of the most important advances in biology. By allowing the site-specific replacement of any amino acid in a protein with one of the other nineteen amino acids, it ushered in the new era of ""Protein Engineering"". The field of protein engineering has, however, evolved rapidly since then and the last fifteen years have witnessed remarkable advances through the use of new chemical, biochemical and molecular biological tools towards the synthesis and manipulation of proteins. The chapters included in this book reflect the rapid evolution of protein engineering and its many applications in basic research, biotechnology, material sciences and therapy. This book will provide the reader with an introduction to state-of the-art concepts and methods and will be of use to anyone interested in the study of proteins, in academia as well as in industry." Full Product DetailsAuthor: Caroline Koehrer , Uttam L. RajBhandaryPublisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K Edition: 2009 ed. Volume: 22 Dimensions: Width: 15.50cm , Height: 2.00cm , Length: 23.50cm Weight: 0.705kg ISBN: 9783540709374ISBN 10: 3540709371 Pages: 347 Publication Date: 28 November 2008 Audience: Professional and scholarly , College/higher education , Professional & Vocational , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsUnderstanding Enzyme Mechanism through Protein Chimeragenesis.- Chemical Protein Engineering: Synthetic and Semisynthetic Peptides and Proteins.- Native Chemical Ligation: SemiSynthesis of Post-translationally Modified Proteins and Biological Probes.- Chemical Methods for Mimicking Post-Translational Modifications.- Noncanonical Amino Acids in Protein Science and Engineering.- Fidelity Mechanisms of the Aminoacyl-tRNA Synthetases.- Specialized Components of the Translational Machinery for Unnatural Amino Acid Mutagenesis: tRNAs, Aminoacyl-tRNA Synthetases, and Ribosomes.- In Vivo Studies of Receptors and Ion Channels with Unnatural Amino Acids.- Synthesis of Modified Proteins Using Misacylated tRNAs.- Cell-Free Synthesis of Proteins with Unnatural Amino Acids. The PURE System and Expansion of the Genetic Code.- Engineering Nucleobases and Polymerases for an Expanded Genetic Alphabet.- Understanding Membrane Proteins. How to Design Inhibitors of Transmembrane Protein—Protein Interactions.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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