Overview

In Protein Dynamics: Methods and Protocols, expert researchers in the field detail both experimental and computational methods to interrogate molecular level fluctuations. Chapters detail best-practice recipes covering both experimental and computational techniques, reflecting modern protein research. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.   Authoritative and practical, Protein Dynamics: Methods and Protocols describes the most common and powerful methods used to characterize protein dynamics.  

Full Product Details

Author:   Dennis R. Livesay
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   Softcover reprint of the original 1st ed. 2014
Volume:   1084
Dimensions:   Width: 17.80cm , Height: 1.60cm , Length: 25.40cm
Weight:   0.780kg
ISBN:  

9781493963072

ISBN 10:   1493963074
Pages:   285
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Monitoring Side-Chain Dynamics of Proteins Using 2H Relaxation.- CPMG Relaxation Dispersion.- Confocal Single-Molecule FRET for Protein Conformational Dynamics.- Protein Structural Dynamics Revealed by Site-directed Spin Labeling and Multifrequency EPR.- Probing Backbone Dynamics With Hydrogen/Deuterium Exchange Mass Spectrometry.- Carbon-Deuterium Bonds as Non-perturbative Infrared Probes of Protein Dynamics, Electrostatics, Heterogeneity, and Folding.- Balancing Bond, Nonbond and Gō-like Terms in Coarse Grain Simulations of Conformational Dynamics.- Tutorial on Building Markov State Models with MSMBuilder and Coarse-graining them with BACE.- Analysis of Protein Conformational Transitions Using Elastic Network Model.- Geometric Simulation of Flexible Motion in Proteins.- Principal Component Analysis: A Method for Determining the Essential Dynamics of Proteins.- A Case Study Comparing Quantitative Stability/Flexibility Relationships Across Five Metallo-β-Lactamases Highlighting Differences within NDM-1.- Towards Comprehensive Analysis of Protein Family Quantitative Stability/Flexibility Relationships using Homology Models.- Using the COREX/BEST Server to Model the Native State Ensemble.- Morphing Methods to Visualize Coarse-grained Protein Dynamics.

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